ArticleNature neuroscience2023
Cerebellar associative learning underlies skilled reach adaptation.
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Cerebellar activity is triggered by reach endpoint during learning of a complex locomotor task.Nature communications · 2026Article
- Behavioral correlates of Purkinje cell ensemble covariance.Nature communications · 2026Article
- The cerebro-cerebellar system: Integrative roles in motor control, cognition, and neuropsychiatric disorders.IBRO neuroscience reports · 2026Review
- A neural language for the cerebellum: control of behavior via competing populations of Purkinje cells.Journal of neurophysiology · 2026Review
- Rapid motor skill adjustment is associated with population-level modulation of cerebellar error signals.Nature neuroscience · 2026Article
- The cerebellum shapes motions by encoding motor frequencies with precision and cross-individual uniformity.Nature biomedical engineering · 2025Article
- Contextual effects during sensorimotor adaptation are an emergent property of population coding in a cerebellar-inspired model.Science advances · 2025Article
- Cerebellar circuit computations for predictive motor control.Nature reviews. Neuroscience · 2025Review
- Effective cerebellar neuroprosthetic control after stroke.Cell reports · 2025Article
- Disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar output.eLife · 2025Article
- Accurate Tracking of Locomotory Kinematics in Mice Moving Freely in Three-Dimensional Environments.eNeuro · 2025Article
- Article
- Purkinje cells of the cerebellum control deceleration of tongue movements.PLoS biology · 2025Article
- A novel biomechanical model of the proximal mouse forelimb predicts muscle activity in optimal control simulations of reaching movements.Journal of neurophysiology · 2025Article
- Control of tongue movements by the Purkinje cells of the cerebellum.bioRxiv : the preprint server for biology · 2025Article
- Review
- Striatal Dopamine Contributions to Skilled Motor Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Open-Source Platform for Kinematic Analysis of Mouse Forelimb Movement.bioRxiv : the preprint server for biology · 2024Article
- The olivary input to the cerebellum dissociates sensory events from movement plans.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A cerebellar population coding model for sensorimotor learning.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The cerebellum is hypothesized to refine movement through online adjustments. We examined how such predictive control may be generated using a mouse reach paradigm, testing whether the cerebellum uses within-reach information as a predictor to adjust reach kinematics. We first identified a population-level response in Purkinje cells that scales inversely with reach velocity, pointing to the cerebellar cortex as a potential site linking kinematic predictors and anticipatory control. Next, we showed that mice can learn to compensate for a predictable reach perturbation caused by repeated, closed-loop optogenetic stimulation of pontocerebellar mossy fiber inputs. Both neural and behavioral readouts showed adaptation to position-locked mossy fiber perturbations and exhibited aftereffects when stimulation was removed. Surprisingly, position-randomized stimulation schedules drove partial adaptation but no opposing aftereffects. A model that recapitulated these findings suggests that the cerebellum may decipher cause-and-effect relationships through time-dependent generalization mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.