Evidence map›Paper›PMID 37248333›Full record

ArticleScientific reports2023

A specific dispiropiperazine derivative that arrests cell cycle, induces apoptosis, necrosis and DNA damage.

Victor P Liu, Wai-Ming Li, Jack Lofroth, Mehreen Zeb, Brian O Patrick, Tina M Bott, Chow H Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Victor P LiuDepartment of Chemistry and Biochemistry, Faculty of Science and Engineering, University of Northern British Columbia, Prince George, BC, V2N 4Z9, Canada.
Wai-Ming LiDepartment of Chemistry and Biochemistry, Faculty of Science and Engineering, University of Northern British Columbia, Prince George, BC, V2N 4Z9, Canada.
Jack LofrothDepartment of Chemistry and Biochemistry, Faculty of Science and Engineering, University of Northern British Columbia, Prince George, BC, V2N 4Z9, Canada.
Mehreen ZebDepartment of Chemistry and Biochemistry, Faculty of Science and Engineering, University of Northern British Columbia, Prince George, BC, V2N 4Z9, Canada.
Brian O PatrickDepartment of Chemistry, University of British Columbia, Vancouver, BC, V6T 1Z1, Canada.
Tina M BottDepartment of Physical Sciences, MacEwan University, 10700-104 Avenue, Edmonton, AB, T5J 4S2, Canada.
Chow H LeeDepartment of Chemistry and Biochemistry, Faculty of Science and Engineering, University of Northern British Columbia, Prince George, BC, V2N 4Z9, Canada. chow.lee@unbc.ca.
University of Northern British Columbia · CAMacEwan University · CAUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dispiropiperazine compounds are a class of molecules known to confer biological activity, but those that have been studied as cell cycle regulators are few in number. Here, we report the characterization and synthesis of two dispiropiperazine derivatives: the previously synthesized spiro[2',3]-bis(acenaphthene-1'-one)perhydrodipyrrolo-[1,2-a:1,2-d]-pyrazine (SPOPP-3, 1), and its previously undescribed isomer, spiro[2',5']-bis(acenaphthene-1'-one)perhydrodipyrrolo-[1,2-a:1,2-d]-pyrazine (SPOPP-5, 2). SPOPP-3 (1), but not SPOPP-5 (2), was shown to have anti-proliferative activity against a panel of 18 human cancer cell lines with IC

Indexed as

Antineoplastic AgentsNeoplasmsAcenaphthenesApoptosisCell CycleCell Cycle CheckpointsCell DivisionCell Line, TumorDNA DamageHumansNecrosisAcenaphthenesAntineoplastic Agents

Identifiers

PMID37248333
PMCPMC10227070
OpenAlexW4378717468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.