ArticleNeuroImage2023
Cardiovascular and metabolic health is associated with functional brain connectivity in middle-aged and older adults: Results from the Human Connectome Project-Aging study.
Article in NeuroImage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Large-Scale Brain Network Connectivity Mediates the Association Between Metabolic Risk Factors and Cognition: An fMRI Study of the Human Connectome Project.International journal of endocrinology and metabolism · 2026Article
- Exploring the link between body physiology and cognition: the role of the brain and aging.npj aging · 2026Article
- Variation in systemic biological health risk is associated with white matter integrity differences in young adult veterans.Brain imaging and behavior · 2026Article
- Functional brain network connectivity patterns associated with midlife metabolic syndrome and cognitive vulnerabilities.Frontiers in aging neuroscience · 2026Article
- Mapping hippocampal-cerebellar functional connectivity across the human adult lifespan.Communications biology · 2025Article
- Molecular pathogenesis of Alzheimer's disease onset in a mouse model: effects of cannabidiol treatment.Frontiers in neuroscience · 2025Article
- MRI Assessment of Cerebral White Matter Microvascular Hemodynamics Across the Adult Lifespan.Journal of magnetic resonance imaging : JMRI · 2024Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Several cardiovascular and metabolic indicators, such as cholesterol and blood pressure have been associated with altered neural and cognitive health as well as increased risk of dementia and Alzheimer's disease in later life. In this cross-sectional study, we examined how an aggregate index of cardiovascular and metabolic risk factor measures was associated with correlation-based estimates of resting-state functional connectivity (FC) across a broad adult age-span (36-90+ years) from 930 volunteers in the Human Connectome Project Aging (HCP-A). Increased (i.e., worse) aggregate cardiometabolic scores were associated with reduced FC globally, with especially strong effects in insular, medial frontal, medial parietal, and superior temporal regions. Additionally, at the network-level, FC between core brain networks, such as default-mode and cingulo-opercular, as well as dorsal attention networks, showed strong effects of cardiometabolic risk. These findings highlight the lifespan impact of cardiovascular and metabolic health on whole-brain functional integrity and how these conditions may disrupt higher-order network integrity.
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Registered trials
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