Evidence map›Paper›PMID 37246900›Full record

ArticleMagnetic resonance in medicine2023

Establishing a hemoglobin adjustment for

Aryil Bechtel, Junlan Lu, David Mummy, Elianna Bier, Suphachart Leewiwatwong, John Mugler, Sakib Kabir, Alex Church, Bastiaan Driehuys

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Dynamic RBC-To-Membrane Ratio inMagnetic resonance in medicine · 2026
    Article
  4. Article
  5. Observational
  6. Mapping the amplitude and phase of dissolvedMagnetic resonance in medicine · 2025
    Article
  7. HyperpolarizedJHLT open · 2024
    Article
  8. Article
  9. Functional gas exchange measures onFrontiers in medicine · 2024
    Article
  10. HyperpolarizedRespiratory medicine
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Aryil BechtelRadiology, Duke University Medical Center, Durham, North Carolina, USA.ORCID 0000-0002-2928-3898
Junlan LuMedical Physics Graduate Program, Duke University, Durham, North Carolina, USA.ORCID 0000-0001-5023-7901
David MummyRadiology, Duke University Medical Center, Durham, North Carolina, USA.ORCID 0000-0001-7885-109X
Elianna BierBiomedical Engineering, Duke University, Durham, North Carolina, USA.ORCID 0000-0002-2313-3450
Suphachart LeewiwatwongBiomedical Engineering, Duke University, Durham, North Carolina, USA.
John MuglerRadiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0002-4140-308X
Sakib KabirRadiology, Duke University Medical Center, Durham, North Carolina, USA.
Alex ChurchRadiology, Duke University Medical Center, Durham, North Carolina, USA.
Bastiaan DriehuysRadiology, Duke University Medical Center, Durham, North Carolina, USA.
Duke Medical Center · USDuke University · USUniversity of Virginia Medical Center · US

Funding

Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRIR01HL105643 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2011 to 2026
$6.7M
Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary FibrosisR01HL126771 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2015 to 2026
$6.6M
Oxidative Stress and Regional Airway Remodeling and Fibrosis in Obese AsthmaR01HL153641 · NHLBI · DUKE UNIVERSITY · PI QUE, LORETTA G · 2020 to 2023
$3.0M
Xenon MRI in Pulmonary HypertensionR01HL153872 · NHLBI · DUKE UNIVERSITY · PI DRIEHUYS, BASTIAAN, RAJAGOPAL, SUDARSHAN K · 2021 to 2024
$2.9M
NHLBI NIH HHS R01 HL105643NHLBI NIH HHS R01 HL126771NHLBI NIH HHS R01 HL153641NHLBI NIH HHS R01 HL153872
6 · The paper itself

Abstract

purpose

methodsWe combined the 1D model of xenon gas exchange (MOXE) with the principle of TR-flip angle equivalence to establish scaling factors that normalize the dissolved-phase signals with respect to a standard

resultsAdjusting for Hb caused RBC/M to change by up to 20% in healthy individuals with normal Hb and had marked impacts on M/gas and RBC/gas distributions in 3D gas-exchange maps. RBC/M was higher in males than females both before and after Hb adjustment (p < 0.001). After Hb adjustment, the healthy reference value for RBC/M for a consortium-recommended acquisition of TR = 15 ms and flip = 20° was 0.589

conclusionMOXE provides a useful framework for evaluating the Hb dependence of the membrane and RBC signals. This work indicates that adjusting for Hb is essential for accurately assessing

Indexed as

Magnetic Resonance ImagingXenon IsotopesAdultErythrocytesFemaleGasesHemoglobinsHumansLungMalePulmonary Gas ExchangeXenonGasesHemoglobinsXenonXenon Isotopeshealthy-reference distributionshemoglobin dependencehyperpolarized 129Xe MRIpulmonary imagingpulmonary spectroscopy

Identifiers

PMID37246900
PMCPMC10524939
OpenAlexW4378640138

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.