Evidence map›Paper›PMID 37246833›Full record

ArticleJournal of cellular and molecular medicine2023

Hypoxic preconditioned mesenchymal stem cells ameliorate rat brain injury after cardiopulmonary resuscitation by suppressing neuronal pyroptosis.

Xiahong Tang, Jun Ke, Falu Chen, Qingming Lin, Yan You, Nan Zheng, Zheng Gong, Xu Han, Yangping Zhuang, Feng Chen

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xiahong TangShengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, China.ORCID 0000-0003-3714-0421
Jun KeShengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, China.
Falu ChenShengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, China.
Qingming LinShengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, China.
Yan YouThe Second Department of Intensive Care Unit, Fujian Provincial Hospital South Branch, Fuzhou, China.
Nan ZhengShengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, China.
Zheng GongShengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, China.
Xu HanShengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, China.
Yangping ZhuangShengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, China.
Feng ChenShengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, China.
Fujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac arrest (CA) can result in cerebral ischaemia-reperfusion injury and poor neurological outcomes. While bone marrow-derived mesenchymal stem cells (BMSCs) have been shown to have protective effects in brain ischaemic disease, their efficacy can be reduced by the poor oxygen environment. In this study, we investigated the neuroprotective effects of hypoxic preconditioned BMSCs (HP-BMSCs) and normoxic BMSCs (N-BMSCs) in a cardiac arrest rat model by examining their ability to ameliorate cell pyroptosis. The mechanism underlying the process was also explored. Cardiac arrest was induced in rats for 8 min and surviving rats received 1 × 10

Indexed as

Brain InjuriesCardiopulmonary ResuscitationHeart ArrestHMGB1 ProteinMesenchymal Stem CellsMesenchymal Stem Cell TransplantationAnimalsHypoxiaNF-kappa BPyroptosisRatsRats, Sprague-DawleyToll-Like Receptor 4HMGB1 ProteinNF-kappa BToll-Like Receptor 4bone marrow-derived mesenchymal stem cellscardiopulmonary resuscitationHMGB1/TLR4/NF-κBhypoxic preconditioningMAPKpyroptosis

Identifiers

PMID37246833
PMCPMC10315812
OpenAlexW4378640242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.