Evidence map›Paper›PMID 37246724›Full record

ArticleThe Journal of infectious diseases2023

Burden of Respiratory Syncytial Virus in the European Union: estimation of RSV-associated hospitalizations in children under 5 years.

Marco Del Riccio, Peter Spreeuwenberg, Richard Osei-Yeboah, Caroline K Johannesen, Liliana Vazquez Fernandez, Anne C Teirlinck, Xin Wang, Terho Heikkinen, Mathieu Bangert, Saverio Caini and 3 more

2 registry-linked trialsOpen access · hybridAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 67 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 6 pooled it
20.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07243236 recruitingnot on this mapstarted 2025, after this paper: background citation

"Assessment of the Impact of Vaccine Funding by the National Health Insurance on Vaccination Coverage Among Patients Targeted by Current Vaccination Recommendations and Followed in Outpatient Consultations in Ile-de-France Region in France""

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2025 to 2027Enrolled2,920ConditionsHealthcare Providers, PostpartumArmsQuestionnaires for patients, Questionnaires for healthcare providers
NCT07346963 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of Demographic, Clinical, and Healthcare Utilization Characteristics of Respiratory Syncytial Virus (RSV) Positive Cases Under 5 Years Presenting to Pediatric Emergency Departments in Türkiye: A Multicenter, Prospective Observational Study (TRUST-RSV)

Typeobservational_patient_registrySponsorEskisehir Osmangazi UniversityRan2026 to 2027Enrolled4,000ConditionsRespiratory Syncytial Virus Infection, Acute Bronchiolitis Due to Respiratory Syncytial Virus, Pneumonia, Upper Respiratory Tract Infection
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 6 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 9 countries.

Marco Del RiccioNetherlands Institute for Health Services Research, Utrecht, The Netherlands.ORCID 0000-0002-2742-0297
Peter SpreeuwenbergNetherlands Institute for Health Services Research, Utrecht, The Netherlands.
Richard Osei-YeboahCentre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0003-4622-3691
Caroline K JohannesenStatens Serum Institut, Copenhagen, Denmark.
Liliana Vazquez FernandezDepartment of Methods Development and Analytics, Norwegian Institute of Public Health, Oslo, Norway.
Anne C TeirlinckCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Xin WangSchool of Public Health, Nanjing Medical University, Nanjing, China.
Terho HeikkinenDepartment of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland.
Mathieu BangertSanofi Vaccines, Lyon, France.
Saverio CainiNetherlands Institute for Health Services Research, Utrecht, The Netherlands.
Harry CampbellCentre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0002-6169-6262
John PagetNetherlands Institute for Health Services Research, Utrecht, The Netherlands.
RESCEU Investigators
Netherlands Institute for Health Services Research · NLUniversity of Edinburgh · GBUniversity of Turku · FICentre for Global Health Research · CANanjing Medical University · CNNational Institute for Public Health and the Environment · NLNorwegian Institute of Public Health · NOSanofi (France) · FRStatens Serum Institut · DK

Funding

European Federation of Pharmaceutical Industries and AssociationsEuropean Union
6 · The paper itself

Abstract

backgroundNo overall estimate of respiratory syncytial virus (RSV)-associated hospitalizations in children aged under 5 years has been published for the European Union (EU). We aimed to estimate the RSV hospitalization burden in children aged under 5 years in EU countries and Norway, by age group.

methodsWe collated national RSV-associated hospitalization estimates calculated using linear regression models via the RESCEU project for Denmark, England, Finland, Norway, the Netherlands, and Scotland, 2006-2018. Additional estimates were obtained from a systematic review. Using multiple imputation and nearest neighbor matching methods, we estimated overall RSV-associated hospitalizations and rates in the EU.

resultsAdditional estimates for 2 countries (France and Spain) were found in the literature. In the EU, an average of 245 244 (95% confidence interval [CI], 224 688-265 799) yearly hospital admissions with a respiratory infection per year were associated with RSV in children aged under 5 years, with most cases occurring among children aged under 1 year (75%). Infants aged under 2 months represented the most affected group (71.6 per 1000 children; 95% CI, 66.6-76.6).

conclusionsOur findings will help support decisions regarding prevention efforts and represent an important benchmark to understand changes in the RSV burden following the introduction of RSV immunization programs in Europe.

Indexed as

Respiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsRespiratory Tract InfectionsChildChild, PreschoolEuropean UnionHospitalizationHumansInfantSystematic Reviews as Topicburden of diseaseEuropehospitalizationmodellingrespiratory hospitalizationrespiratory syncytial virus

Identifiers

PMID37246724
PMCPMC10681872
OpenAlexW4378640399

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.