Evidence map›Paper›PMID 37246224›Full record

ArticleJournal of translational medicine2023

Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort.

Maryia Khomich, Huang Lin, Andrei Malinovschi, Susanne Brix, Lucia Cestelli, Shyamal Peddada, Ane Johannessen, Carsten Eriksen, Francisco Gomez Real, Cecilie Svanes and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 4 countries.

Maryia KhomichDepartment of Clinical Science, University of Bergen, Bergen, Norway. maryia.khomich@uib.no.ORCID 0000-0002-6840-5739
Huang LinBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle Park, Durham, NC, USA.
Andrei MalinovschiDepartment of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.
Susanne BrixDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Lucia CestelliDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Shyamal PeddadaBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle Park, Durham, NC, USA.
Ane JohannessenDepartment of Global Public Health and Primary Care, Center for International Health, University of Bergen, Bergen, Norway.
Carsten EriksenDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Francisco Gomez RealDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Cecilie SvanesDepartment of Global Public Health and Primary Care, Center for International Health, University of Bergen, Bergen, Norway.
Randi Jacobsen BertelsenDepartment of Clinical Science, University of Bergen, Bergen, Norway. randi.j.bertelsen@uib.no.ORCID 0000-0001-5319-525X
University of Bergen · NOHaukeland University Hospital · NONational Institute of Environmental Health Sciences · USAalborg University · DKTechnical University of Denmark · DKUppsala University · SEWestern Norway University of Applied Sciences · NO

Funding

Collaborative Biostatistical ResearchZIAES103390 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI PEDDADA, SHYAMAL · 2023 to 2025
$665k
European Research Council 804199
6 · The paper itself

Abstract

backgroundLipid A is the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule. The inflammatory response of LPS varies and depends upon the number of acyl chains and phosphate groups in lipid A which is specific for a bacterial species or strain. Traditional LPS quantification assays cannot distinguish between the acylation degree of lipid A molecules, and therefore little is known about how bacteria with different inflammation-inducing potencies affect fractional exhaled nitric oxide (F

methodsWe used data from a population-based adult cohort from Norway (n = 477), a study center of the RHINESSA multi-center generation study. We applied statistical methods on the bacterial community- (prediction with MiRKAT) and genus-level (differential abundance analysis with ANCOM-BC) to investigate the association between the oral microbiota composition and F

resultsWe found the overall composition to be significantly associated with increasing F

conclusionsIn a population-based adult cohort, F

Indexed as

Lipid ALipopolysaccharidesAdultBacteriaFractional Exhaled Nitric Oxide TestingHumansInflammationNitric OxideLipid ALipopolysaccharidesNitric OxideAirway inflammationANCOM-BCBacteriaEndotoxinExhaled nitric oxideLipid ALipopolysaccharideMiRKATOral microbiotaRHINESSA

Identifiers

PMID37246224
PMCPMC10226232
OpenAlexW4378628066

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.