Evidence map›Paper›PMID 37246148›Full record

ArticleInfluenza and other respiratory viruses2023

Risk factors for infection with influenza A(H3N2) virus on a US university campus, October-November 2021.

Nathaniel M Lewis, Miranda J Delahoy, Kelsey M Sumner, Adam S Lauring, Emily E Bendall, Lindsey Mortenson, Elizabeth Edwards, Aleksandra Stamper, Brendan Flannery, Emily T Martin

Open access · goldAbstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Nathaniel M LewisInfluenza Division, National Center for Immunization and Respiratory Diseases, CDC, Atlanta, Georgia, USA.ORCID 0000-0001-7088-9640
Miranda J DelahoyInfluenza Division, National Center for Immunization and Respiratory Diseases, CDC, Atlanta, Georgia, USA.
Kelsey M SumnerInfluenza Division, National Center for Immunization and Respiratory Diseases, CDC, Atlanta, Georgia, USA.ORCID 0000-0002-4479-897X
Adam S LauringUniversity of Michigan School of Medicine, Ann Arbor, Michigan, USA.ORCID 0000-0003-2906-8335
Emily E BendallUniversity of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Lindsey MortensonUniversity of Michigan University Health Service, Ann Arbor, Michigan, USA.
Elizabeth EdwardsUniversity of Michigan University Health Service, Ann Arbor, Michigan, USA.
Aleksandra StamperUniversity of Michigan University Health Service, Ann Arbor, Michigan, USA.
Brendan FlanneryInfluenza Division, National Center for Immunization and Respiratory Diseases, CDC, Atlanta, Georgia, USA.ORCID 0000-0001-5041-308X
Emily T MartinUniversity of Michigan School of Public Health, Ann Arbor, Michigan, USA.ORCID 0000-0002-5771-8895
University of Michigan · USNational Center for Immunization and Respiratory Diseases · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKnowledge of the specific dynamics of influenza introduction and spread in university settings is limited.

methodsPersons with acute respiratory illness symptoms received influenza testing by molecular assay during October 6-November 23, 2022. Viral sequencing and phylogenetic analysis were conducted on nasal swab samples from case-patients. Case-control analysis of a voluntary survey of persons tested was used to identify factors associated with influenza; logistic regression was conducted to calculate odds ratios and 95% CIs. A subset of case-patients tested during the first month of the outbreak was interviewed to identify sources of introduction and early spread.

resultsAmong 3268 persons tested, 788 (24.1%) tested positive for influenza; 744 (22.8%) were included in the survey analysis. All 380 sequenced specimens were influenza A (H3N2) virus clade 3C.2a1b.2a.2, suggesting rapid transmission. Influenza (OR [95% CI]) was associated with indoor congregate dining (1.43 [1.002-2.03]), attending large gatherings indoors (1.83 [1.26-2.66]) or outdoors (2.33 [1.64-3.31]), and varied by residence type (apartment with ≥1 roommate: 2.93 [1.21-7.11], residence hall room alone: 4.18 [1.31-13.31], or with roommate: 6.09 [2.46-15.06], or fraternity/sorority house: 15.13 [4.30-53.21], all compared with single-dwelling apartment). Odds of influenza were lower among persons who left campus for ≥1 day during the week before their influenza test (0.49 [0.32-0.75]). Almost all early cases reported attending large events.

conclusionsCongregate living and activity settings on university campuses can lead to rapid spread of influenza following introduction. Isolating following a positive influenza test or administering antiviral medications to exposed persons may help mitigate outbreaks.

Indexed as

Influenza A virusInfluenza, HumanHumansInfluenza A Virus, H3N2 SubtypePhylogenyRisk FactorsUniversitiescongregate settingsinfluenzarespiratory infectionsrespiratory virusesrisk factorsstudent health

Identifiers

PMID37246148
PMCPMC10209643
OpenAlexW4378176467

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.