ArticleNeuroImage2023
Allostatic-interoceptive anticipation of social rejection.
Article in NeuroImage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Heartbeat-Evoked Responses in M/EEG: A Systematic Review of Methods With Suggestions for Analysis and Reporting.Psychophysiology · 2026Pooled it
- Loneliness exacerbates age differences in the -allostatic-interoceptive system during induced affect.Social cognitive and affective neuroscience · 2026Article
- Perceived socioeconomic vulnerability, but not objective poverty, is linked to interoception through perceived stress.Frontiers in psychology · 2026Article
- Cortical and subcortical mapping of the human allostatic-interoceptive system using 7 Tesla fMRI.Nature neuroscience · 2025Article
- Cortical and subcortical mapping of the allostatic-interoceptive system in the human brain using 7 Tesla fMRI.bioRxiv : the preprint server for biology · 2025Article
- Impaired interoception in Colombian victims of armed conflict with PTSD: a preliminary HEP study.Frontiers in psychology · 2025Article
- Allostatic Interoceptive Overload Across Psychiatric and Neurological Conditions.Biological psychiatry · 2025Review
- Emerging Theories of Allostatic-Interoceptive Overload in Neurodegeneration.Current topics in behavioral neurosciences · 2025Review
- A synergetic turn in cognitive neuroscience of brain diseases.Trends in cognitive sciences · 2024Review
- The Human Affectome.Neuroscience and biobehavioral reviews · 2024Review
- Intrinsic timescales and predictive allostatic interoception in brain health and disease.Neuroscience and biobehavioral reviews · 2024Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Anticipating social stress evokes strong reactions in the organism, including interoceptive modulations. However, evidence for this claim comes from behavioral studies, often with inconsistent results, and relates almost solely to the reactive and recovery phase of social stress exposure. Here, we adopted an allostatic-interoceptive predictive coding framework to study interoceptive and exteroceptive anticipatory brain responses using a social rejection task. We analyzed the heart-evoked potential (HEP) and task-related oscillatory activity of 58 adolescents via scalp EEG, and 385 human intracranial recordings of three patients with intractable epilepsy. We found that anticipatory interoceptive signals increased in the face of unexpected social outcomes, reflected in larger negative HEP modulations. Such signals emerged from key brain allostatic-interoceptive network hubs, as shown by intracranial recordings. Exteroceptive signals were characterized by early activity between 1-15 Hz across conditions, and modulated by the probabilistic anticipation of reward-related outcomes, observed over distributed brain regions. Our findings suggest that the anticipation of a social outcome is characterized by allostatic-interoceptive modulations that prepare the organism for possible rejection. These results inform our understanding of interoceptive processing and constrain neurobiological models of social stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.