Evidence map›Paper›PMID 37245180›Full record

ArticleInternational journal of computer assisted radiology and surgery2023

Development and validation of a radiofrequency ablation treatment planning system for vertebral metastases.

Cari M Whyne, Grace Underwood, Sean R H Davidson, Normand Robert, Christine Huang, Margarete K Akens, Gabor Fichtinger, Albert J M Yee, Michael Hardisty

Abstract read
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In one paragraph

Article in International journal of computer assisted radiology and surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Cari M WhyneOrthopaedic Biomechanics Lab, Holland Bone and Joint Program, Sunnybrook Research Institute, Toronto, ON, Canada. cari.whyne@sunnybrook.ca.
Grace UnderwoodSchool of Computing, Queen's University, Kingston, ON, Canada.
Sean R H DavidsonTechna Institute, University Health Network, Toronto, ON, Canada.
Normand RobertOrthopaedic Biomechanics Lab, Holland Bone and Joint Program, Sunnybrook Research Institute, Toronto, ON, Canada.
Christine HuangOrthopaedic Biomechanics Lab, Holland Bone and Joint Program, Sunnybrook Research Institute, Toronto, ON, Canada.
Margarete K AkensDepartment of Surgery, University of Toronto, Toronto, ON, Canada.
Gabor FichtingerSchool of Computing, Queen's University, Kingston, ON, Canada.
Albert J M YeeOrthopaedic Biomechanics Lab, Holland Bone and Joint Program, Sunnybrook Research Institute, Toronto, ON, Canada.
Michael HardistyOrthopaedic Biomechanics Lab, Holland Bone and Joint Program, Sunnybrook Research Institute, Toronto, ON, Canada.
Sunnybrook Hospital · CAQueen's University · CAUniversity of Toronto · CASunnybrook Research InstituteUniversity Health Network · CA

Funding

Collaborative Health Research Grant (CHRP) 493843-16
6 · The paper itself

Abstract

purposeBone-targeted radiofrequency ablation (RFA) is widely used in the treatment of vertebral metastases. While radiation therapy utilizes established treatment planning systems (TPS) based on multimodal imaging to optimize treatment volumes, current RFA of vertebral metastases has been limited to qualitative image-based assessment of tumour location to direct probe selection and access. This study aimed to design, develop and evaluate a computational patient-specific RFA TPS for vertebral metastases.

methodsA TPS was developed on the open-source 3D slicer platform, including procedural setup, dose calculation (based on finite element modelling), and analysis/visualization modules. Usability testing was carried out by 7 clinicians involved in the treatment of vertebral metastases on retrospective clinical imaging data using a simplified dose calculation engine. In vivo evaluation was performed in a preclinical porcine model (n = 6 vertebrae).

resultsDose analysis was successfully performed, with generation and display of thermal dose volumes, thermal damage, dose volume histograms and isodose contours. Usability testing showed an overall positive response to the TPS as beneficial to safe and effective RFA. The in vivo porcine study showed good agreement between the manually segmented thermally damaged volumes vs. the damage volumes identified from the TPS (Dice Similarity Coefficient = 0.71 ± 0.03, Hausdorff distance = 1.2 ± 0.1 mm).

conclusionA TPS specifically dedicated to RFA in the bony spine could help account for tissue heterogeneities in both thermal and electrical properties. A TPS would enable visualization of damage volumes in 2D and 3D, assisting clinicians in decisions about potential safety and effectiveness prior to performing RFA in the metastatic spine.

Indexed as

Catheter AblationRadiofrequency AblationAnimalsHumansRetrospective StudiesSpineSwineIn vivo preclinical validationRadiofrequency ablationThermal dose estimationTreatment planning systemUsability assessmentVertebral metastases

Identifiers

PMID37245180
OpenAlexW4378570615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.