Evidence map›Paper›PMID 37245038›Full record

ArticleBMC pregnancy and childbirth2023

Effect of prophylactic antiviral intervention on T cell immunity in hepatitis B virus-infected pregnant women.

Meiting Huang, Yunfei Gao, Dandan Liao, Yanchen Ma, Jinna Li, Bo Tang, Yaohua Hao, Xuelian Zhang, Shimin Yin, Xiaohuan Jiang and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Meiting Huang *Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yunfei Gao *Department of Obstetrics and Gynaecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Dandan LiaoDepartment of Obstetrics and Gynaecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yanchen MaDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Jinna LiDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Bo TangDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yaohua HaoDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Xuelian ZhangDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Shimin YinDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Xiaohuan JiangDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Jialin LiDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Xueru YinDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yongyin LiDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Jing HuDepartment of Nosocomial Infection Administration, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China. hjalzh@sum.edu.cn.
Zhihua LiuDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. zhihualiu@126.com.
Southern Medical University · CNNanfang Hospital · CN

Funding

National Key Research and Development Program of China No.2022YFC2303600National Natural Science Foundation of China Grant No.81673243
6 · The paper itself

Abstract

backgroundAntiviral intervention in hepatitis B virus (HBV)-infected pregnant women can effectively reduce mother-to-child transmission. However, the immunological characteristics of pregnant women with chronic HBV infection and the effects of antiviral intervention during pregnancy on maternal immune response remain unknown. We aimed to investigate these effects by comparing mothers who received antiviral intervention during pregnancy with those who did not.

methodsPregnant women positive for hepatitis B surface antigen and hepatitis B e-antigen (HBsAg

resultsAt delivery, maternal regulatory T cell (Treg) frequency in AVI mothers was significantly higher than that in NAVI mothers (P < 0.002), and CD4

conclusionsProphylactic antiviral intervention during pregnancy has an effect on T cell immunity in pregnant women, which was characterised by increased maternal Treg frequency, enhanced Th2 response and suppressed Th1 response at delivery.

Indexed as

Hepatitis BPregnancy Complications, InfectiousAntiviral AgentsCD8-Positive T-LymphocytesDNA, ViralFemaleHepatitis B e AntigensHepatitis B Surface AntigensHepatitis B virusHumansInfectious Disease Transmission, VerticalInterleukin-10PregnancyPregnant PeopleAntiviral AgentsDNA, ViralHepatitis B e AntigensHepatitis B Surface AntigensInterleukin-10Antiviral interventionHepatitis B virusPregnant womenRegulatory T cellT helper cell

Identifiers

PMID37245038
PMCPMC10223933
OpenAlexW4378573859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.