ArticleBMC oral health2023
Longitudinal association of edentulism with cognitive impairment, sarcopenia and all-cause mortality among older Chinese adults.
Article in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.
- Deteriorated oral health and function as risk factors for physical disability and mortality in community-dwelling older adults: a systematic review and meta-analysis.European geriatric medicine · 2026Pooled it
- Dentition-Cognition Relationship in Aging Populations: A Meta-Analysis of Longitudinal Data.Journal of oral rehabilitation · 2026Pooled it
- Association Between Oral Frailty and Cognitive Impairment in Older Adults: A Cross-sectional Study.International dental journal · 2026Article
- Bidirectional association between edentulism and sarcopenia in Chinese middle-aged and older adults: a nationally representative longitudinal cohort study.Clinical oral investigations · 2026Observational
- Masticatory function and frailty: insights from NHANES and CHARLS.BMC public health · 2026Article
- Oral Function, Frailty and Mortality in Older Adults: Evidence from the Chilean National Health Survey 2016-2017.International journal of environmental research and public health · 2026Article
- Divergent effects of oral health and genetic risk: competing risks of dementia and mortality.Innovation in aging · 2026Article
- Unraveling the causal association of epigenetic age acceleration with common oral diseases and its underlying mechanisms: findings from Mendelian randomization and integrative genetic analysis.Clinical epigenetics · 2025Article
- Characterization of craniofacial tissue aging in genetically diverse HET3 male mice with longevity treatment of 17-alpha estradiol.Archives of oral biology · 2025Article
- Oral Health Status and Factors Associated with Oral Health in Patients with Alzheimer's Disease: A Matched Case-Control Observational Study.Journal of clinical medicine · 2025Article
- Tooth loss trajectories and their association with all-cause mortality among older Chinese adults.Frontiers in oral health · 2025Article
- The association between edentulism and cardiometabolic multimorbidity in US middle-aged and older adults.The journal of nutrition, health & aging · 2024Article
- The impact of physical activity on the prevalence of edentulism: an analysis of the relationships between active lifestyle and dental health.BMC public health · 2024Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTooth loss may be a surrogate for systemic health and aging. However, no previous studies have systematically assessed multiple outcomes relevant to aging trajectory in this area, and many important confounders were not adjusted in most previous studies. This study aims to prospectively evaluate the associations of complete tooth loss (edentulism) with broad markers of sarcopenia, cognitive impairment and mortality.
methodsData were derived from the China Health and Retirement Longitudinal Study, a nationally representative household study of the Chinese population aged 45 years and older. Multivariate Weibull proportional hazards regression was used to assess the association between edentulism with sarcopenia and all-cause mortality. Average changes in cognitive function by edentulism was estimated by mixed-effects linear regression models.
resultsDuring the 5-year follow-up, the prevalence of edentulism among adults aged 45 and over was 15.4%. Participants with edentulism had a greater decline in cognitive function compared to those without (β=-0.70, 95%CI:-1.09, -0.31, P < 0.001). The association of edentulism and all-cause mortality for 45-64 age group (HR = 7.50, 95%CI: 1.99, 28.23, P = 0.003), but not statistically significant for the ≥ 65 age group (HR = 2.37, 95%CI: 0.97, 5.80, P = 0.057). Effects of edentulism on sarcopenia are statistically significant for all age groups (45-64 age group: HR = 2.15, 95%CI: 1.27, 3.66, P = 0.005; ≥65 age group: HR = 2.15, 95%CI: 1.27, 3.66, P = 0.002).
conclusionsThese findings could have important clinical and public health implications, as tooth loss is a quick and reproducible measurement that could be used in clinical practice for identifying persons at risk of accelerated aging and shortened longevity, and who may benefit most from intervention if causality is established.
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