Evidence map›Paper›PMID 37244910›Full record

ArticleNature communications2023

Photoinhibiting via simultaneous photoabsorption and free-radical reaction for high-fidelity light-based bioprinting.

Ning He, Xiaonan Wang, Liyang Shi, Jing Li, Lan Mo, Feng Chen, Yuting Huang, Hairong Liu, Xiaolong Zhu, Wei Zhu and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ning HeNational Engineering Research Centre for High Efficiency Grinding, Hunan University, 410082, Changsha, China.ORCID 0000-0003-0016-3283
Xiaonan WangCollege of Biology, Hunan University, 410082, Changsha, China.
Liyang ShiCollege of Biology, Hunan University, 410082, Changsha, China.ORCID 0000-0002-2422-7280
Jing LiNational Engineering Research Centre for High Efficiency Grinding, Hunan University, 410082, Changsha, China.ORCID 0000-0002-2345-2304
Lan MoCollege of Food Science and Technology, Hunan Agricultural University, 410128, Changsha, China.
Feng ChenNational Engineering Research Centre for High Efficiency Grinding, Hunan University, 410082, Changsha, China. fchen@hnu.edu.cn.ORCID 0000-0003-0630-6812
Yuting HuangCollege of Material Science and Engineering, Hunan University, 410082, Changsha, China.
Hairong LiuCollege of Material Science and Engineering, Hunan University, 410082, Changsha, China.
Xiaolong ZhuNational Engineering Research Centre for High Efficiency Grinding, Hunan University, 410082, Changsha, China.ORCID 0000-0001-7510-3651
Wei ZhuNational Engineering Research Centre for High Efficiency Grinding, Hunan University, 410082, Changsha, China.ORCID 0000-0003-0148-6236
Yiqi MaoNational Engineering Research Centre for High Efficiency Grinding, Hunan University, 410082, Changsha, China.
Xiaoxiao HanNational Engineering Research Centre for High Efficiency Grinding, Hunan University, 410082, Changsha, China. xiaoxiaohan@hnu.edu.cn.ORCID 0000-0003-3007-6519

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Light-based 3D bioprinting is now employed widely to fabricate geometrically complex constructs for various biomedical applications. However, the inherent light scattering defect creates significant challenges in patterning dilute hydrogels to form high-fidelity structures with fine-scale features. Herein, we introduce a photoinhibiting approach that can effectively suppress the light scattering effect via a mechanism of simultaneous photoabsorption and free-radical reaction. This biocompatible approach significantly improves the printing resolution (~1.2 - ~2.1 pixels depending on swelling) and shape fidelity (geometric error less than 5%), while minimising the costly trial-and-error procedures. The capability in patterning 3D complex constructs using different hydrogels is demonstrated by manufacturing various scaffolds featuring intricate multi-sized channels and thin-walled networks. Importantly, cellularised gyroid scaffolds (HepG2) are fabricated successfully, exhibiting high cell proliferation and functionality. The strategy established in this study promotes the printability and operability of light-based 3D bioprinting systems, allowing numerous new applications for tissue engineering.

Indexed as

BioprintingTissue ScaffoldsHydrogelsPrinting, Three-DimensionalTissue EngineeringHydrogels

Identifiers

PMID37244910
PMCPMC10224992

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.