ArticleThe Lancet. Public health2023
Adverse childhood experiences and adolescent cannabis use trajectories: findings from a longitudinal UK birth cohort.
Article in The Lancet. Public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- ADHD Symptoms and Cannabis Use: The Role of Cannabinoid Receptor 1 and Neural Response Inhibition.medRxiv : the preprint server for health sciences · 2026Article
- Predicting Substance Use in Young Adults: The Role of Childhood Adversity.Medicina (Kaunas, Lithuania) · 2026Article
- Associations between posttraumatic cognitions and cannabis cravings among trauma-exposed individuals using cannabis.The British journal of clinical psychology · 2026Article
- The relationship between Problem Gambling Severity Index scores and suicidality: Results of a 9-year cohort study of young United Kingdom adults.Addiction (Abingdon, England) · 2026Article
- Childhood events as factors in continued cannabis use in adulthood: a longitudinal study of a 30-year follow-up cohort.Journal of cannabis research · 2025Article
- Longitudinal study of risk factors predicting cannabis use disorder in UK young adults and adolescents.Communications medicine · 2025Article
- Associations of childhood adversity and substance use disorder polygenic scores with disorder severity and diagnostic criteria.Psychological medicine · 2025Article
- Childhood Sexual Trauma, Substance Use, and Antiretroviral Therapy Adherence Among Older Adults Living With HIV: A Mediational Analysis.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025Article
- The Developmental Trajectory to Cannabis Use Disorder.The American journal of psychiatry · 2024Article
- The Role of Childhood Trauma in Chronic Pain and Substance Use Among Individuals Receiving Methadone Treatment for Opioid Use Disorder.Journal of addiction medicineArticle
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Authors and funding
7 authors.
Funding
Abstract
backgroundAdverse childhood experiences (ACEs) are classically defined as physical abuse, sexual abuse, emotional abuse, emotional neglect, bullying, parental substance use or abuse, violence between parents, parental mental health problems or suicide, parental separation, or a parent convicted of criminal offence. Exposure to ACEs can be associated with cannabis use, but no comparisons across all adversities have been made while also considering timing and frequency of cannabis use. We aimed to explore the association between ACEs and cannabis use timing and frequency in adolescence, considering the cumulative number of ACEs and individual ACEs.
methodsWe used data from the Avon Longitudinal Study of Parents and Children, a longitudinal UK birth cohort study. Longitudinal latent classes of cannabis use frequency were derived from self-reported data at multiple timepoints in participants aged 13-24 years. ACEs between ages 0 years and 12 years were derived from prospective and retrospective reports at multiple timepoints by parents and the participant. Multinomial regression was used to analyse the effect of both cumulative exposure to all ACEs and the ten individual ACEs on cannabis use outcomes.
findings5212 participants (3132 [60·0%] were female and 2080 [40·0%] were male; 5044 [96·0%] were White and 168 [4·0%] were Black, Asian, or minority ethnic) were included in this study. After adjustment for polygenic risk and environmental risk factors, participants who had 4 or more ACEs at age 0-12 years were at increased risk of early persisting regular cannabis use (relative risk ratio [RRR] 3·15 [95% CI 1·81-5·50]), later onset regular use (1·99 [1·14-3·74]), and early persisting occasional use (2·55 [1·74-3·73]) compared with low or no cannabis use. After adjustment, early persisting regular use was associated with parental substance use or abuse (RRR 3·90 [95% CI 2·10-7·24]), parental mental health problems (2·02 [1·26-3·24]), physical abuse (2·27 [1·31-3·98]), emotional abuse (2·44 [1·49-3·99]), and parental separation (1·88 [1·08-3·27]) compared with low or no cannabis use.
interpretationRisks for problematic adolescent cannabis use are highest for individuals reporting 4 or more ACEs, and were particularly raised for those with parental substance use or abuse. Public health measures to address ACEs might reduce adolescent cannabis use.
fundingThe Wellcome Trust, UK Medical Research Council, Alcohol Research UK.
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