Evidence map›Paper›PMID 37244600›Full record

ArticleMolecular and cellular endocrinology2023

Differential roles of insulin receptor in adipocyte progenitor cells in mice.

Yexian Yuan, Zuoxiao Shi, Shaolei Xiong, Ruoci Hu, Qing Song, Zhenyuan Song, Sang-Ging Ong, Yuwei Jiang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yexian YuanGuangdong Laboratory of Lingnan Modern Agriculture, Guangdong Province Key Laboratory of Animal Nutritional Regulation and National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China; Department of Physiology and Biophysics, The University of Illinois at Chicago, Chicago, IL, 60612, USA.
Zuoxiao ShiDepartment of Physiology and Biophysics, The University of Illinois at Chicago, Chicago, IL, 60612, USA; Department of Pharmaceutical Sciences, The University of Illinois at Chicago, Chicago, IL, 60612, USA.
Shaolei XiongDepartment of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Ruoci HuDepartment of Physiology and Biophysics, The University of Illinois at Chicago, Chicago, IL, 60612, USA; Department of Pharmaceutical Sciences, The University of Illinois at Chicago, Chicago, IL, 60612, USA.
Qing SongDepartment of Kinesiology and Nutrition, The University of Illinois at Chicago, Chicago, IL, 60612, USA.
Zhenyuan SongDepartment of Kinesiology and Nutrition, The University of Illinois at Chicago, Chicago, IL, 60612, USA.
Sang-Ging OngDepartment of Pharmacology and Regenerative Medicine, College of Medicine, The University of Illinois at Chicago, Illinois, 60612, USA; Division of Cardiology, Department of Medicine, The University of Illinois College of Medicine, Illinois, 60612, USA.
Yuwei JiangDepartment of Physiology and Biophysics, The University of Illinois at Chicago, Chicago, IL, 60612, USA; Department of Pharmaceutical Sciences, The University of Illinois at Chicago, Chicago, IL, 60612, USA; Division of Endocrinology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. Electronic address: yuweij@uic.edu.
University of Illinois Chicago · USIllinois College · USSouth China Agricultural University · CN

Funding

Regulation of beige adipocyte maintenance and its impact on metabolic outcomesR01DK132398 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Yuwei Jiang · 2022 to 2026
$2.6M
Rab GTPases-mediated mitochondrial clearance in diabetic cardiomyopathyR01HL148756 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ONG, SANG GING · 2020 to 2024
$2.4M
Central nervous system-adipose tissue axis in the pathogenesis of alcoholic liver diseaseR01AA026603 · NIAAA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SONG, ZHENYUAN · 2018 to 2022
$1.8M
Molecular regulation of adipose tissue development, homeostasis and expansionK01DK111771 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JIANG, YUWEI · 2016 to 2021
$705k
Regulation of adipose lineage plasticity in obesityR03DK127149 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI JIANG, YUWEI · 2021 to 2022
$240k
NHLBI NIH HHS R01 HL148756NIAAA NIH HHS R01 AA026603NIDDK NIH HHS K01 DK111771NIDDK NIH HHS R01 DK132398NIDDK NIH HHS R03 DK127149
6 · The paper itself

Abstract

The development of white adipose tissue (WAT) occurs during distinct embryonic and postnatal stages, and it is subsequently maintained throughout life. However, the specific mediators and mechanisms responsible for WAT development during different phases remain unclear. In this study, we investigate the role of the insulin receptor (IR) in regulating adipogenesis and adipocyte function within adipocyte progenitor cells (APCs) during WAT development and homeostasis. We use two in vivo adipose lineage tracking and deletion systems to delete IR either in embryonic APCs or adult APCs, respectively, to explore the specific requirements of IR during WAT development and WAT homeostasis in mice. Our data suggest that IR expression in APCs may not be essential for adult adipocyte differentiation but appears to be crucial for adipose tissue development. We reveal a surprising divergent role of IR in APCs during WAT development and homeostasis.

Indexed as

AdipocytesReceptor, InsulinAdipogenesisAdipose Tissue, WhiteAnimalsMiceObesityStem CellsReceptor, InsulinAdipocyte progenitor cellsAdipose tissue developmentInsulin receptorLipodystrophyTissue homeostasis

Identifiers

PMID37244600
PMCPMC10846871
OpenAlexW4378191103

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.