Evidence map›Paper›PMID 37244562›Full record

ArticleNeurotoxicology2023

Assessing CaMPARI as new approach methodology for evaluating neurotoxicity.

Dana Biechele-Speziale, Manuel Camarillo, Nathan R Martin, John Biechele-Speziale, Pamela J Lein, Jessica S Plavicki

Open access · greenAbstract read
In one paragraph

Article in Neurotoxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Dana Biechele-SpezialeDepartment of Chemistry, Brown University, Providence, RI, USA; Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Manuel CamarilloDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Nathan R MartinDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
John Biechele-SpezialeSchool of Industrial Engineering, Purdue University, West Lafayette, IN, USA.
Pamela J LeinDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
Jessica S PlavickiDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA. Electronic address: jessica_plavicki@brown.edu.
Brown University · USPurdue University West Lafayette · USUniversity of California, Davis · US

Funding

UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Nicholas J. KENYON · 2015 to 2026
$26.0M
Uncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes MellitusP20GM103652 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI HARRINGTON, ELIZABETH O · 2013 to 2022
$21.3M
Molecular and Cellular Basis of PCB Developmental Neurotoxicity: ViCTER supplementR01ES014901 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HANS-JOACHIM LEHMLER, Pamela J Lein · 2009 to 2026
$9.3M
Toxicant Induced dysregulation of parvalbumin interneuron development and functionR01ES030109 · NIEHS · BROWN UNIVERSITY · PI PLAVICKI, JESSICA SUSAN · 2020 to 2024
$2.2M
Short-Term Training Program to Increase Diversity in Health-Related ResearchR25HL088992 · NHLBI · BROWN UNIVERSITY · PI ABID, RUHUL, DIAZ, JOSEPH A · 2007 to 2024
$1.9M
NHLBI NIH HHS R25 HL088992NIEHS NIH HHS P30 ES023513NIEHS NIH HHS R01 ES014901NIEHS NIH HHS R01 ES030109NIGMS NIH HHS P20 GM103652
6 · The paper itself

Abstract

Developmental exposure to environmental toxicants has been linked to the onset of neurological disorders and diseases. Despite substantial advances in the field of neurotoxicology, there remain significant knowledge gaps in our understanding of cellular targets and molecular mechanisms that mediate the neurotoxicological endpoints associated with exposure to both legacy contaminants and emerging contaminants of concern. Zebrafish are a powerful neurotoxicological model given their high degree sequence conservation with humans and the similarities they share with mammals in micro- and macro-level brain structures. Many zebrafish studies have effectively utilized behavioral assays to predict the neurotoxic potential of different compounds, but behavioral phenotypes are rarely able to predict the brain structures, cell types, or mechanisms affected by chemical exposures. Calcium-modulated photoactivatable ratiometric integrator (CaMPARI), a recently developed genetically-encoded calcium indicator, undergoes a permanent green to red switch in the presence of elevated intracellular Ca

Indexed as

CalciumNeurotoxicity SyndromesAnimalsBrainHumansMammalsNeuronsSwimmingZebrafishCalciumBehaviorCaMPARINeurotoxicityZebrafish

Identifiers

PMID37244562
PMCPMC10527633
OpenAlexW4378211274

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.