Evidence map›Paper›PMID 37244064›Full record

ArticleJournal of psychiatric research2023

Smaller cornu ammonis (CA3) as a potential risk factor for suicidal behavior in mood disorders.

Spiro P Pantazatos, Todd Ogden, Nadine M Melhem, David A Brent, Mohammad Lesanpezeshki, Ainsley Burke, John G Keilp, Jeffrey M Miller, J John Mann

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Spiro P PantazatosMolecular Imaging and Neuropathology Area, New York State Psychiatric Institute, New York, NY, USA; Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: spp2101@columbia.edu.
Todd OgdenMolecular Imaging and Neuropathology Area, New York State Psychiatric Institute, New York, NY, USA; Mailman School of Public Health, Columbia University, New York, USA.
Nadine M MelhemDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
David A BrentDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Mohammad LesanpezeshkiMolecular Imaging and Neuropathology Area, New York State Psychiatric Institute, New York, NY, USA; Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Ainsley BurkeMolecular Imaging and Neuropathology Area, New York State Psychiatric Institute, New York, NY, USA; Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
John G KeilpMolecular Imaging and Neuropathology Area, New York State Psychiatric Institute, New York, NY, USA; Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Jeffrey M MillerMolecular Imaging and Neuropathology Area, New York State Psychiatric Institute, New York, NY, USA; Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
J John MannMolecular Imaging and Neuropathology Area, New York State Psychiatric Institute, New York, NY, USA; Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: jjm@columbia.edu.
Columbia University Irving Medical Center · USNew York State Psychiatric InstituteUniversity of Pittsburgh · USColumbia University · US

Funding

Suicidal Behavior: Aggression Subtypes, Childhood Adversity and Stress ResponseP50MH090964 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MANN, JOSEPH JOHN · 2013 to 2022
$23.6M
Neurobiology of Depression and AntidepressantsR01MH040695 · NIMH · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI MANN, JOSEPH JOHN · 1986 to 2014
$7.1M
Familial Pathways to Early-OnSet Suicide AttemptsR01MH056390 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MANN, JOSEPH JOHN · 2002 to 2013
$4.5M
1/2 Inflammation and Stress Response in Familial and Nonfamilial Youth Suicidal BehaviorR01MH108039 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Nadine M. Melhem · 2015 to 2026
$3.2M
2/2 - Inflammation and Stress Response in Familial and Nonfamilial Youth Suicidal BehaviorR01MH108032 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MANN, JOSEPH JOHN · 2015 to 2023
$2.7M
FAMILIAL PATHWAYS TO EARLY ONSET SUICIDE ATTEMPTSR10MH056390 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE · PI MANN, JOSEPH J · 1997 to 2001
$1.1M
NIMH NIH HHS P50 MH090964NIMH NIH HHS R01 MH040695NIMH NIH HHS R01 MH056390NIMH NIH HHS R01 MH108032NIMH NIH HHS R01 MH108039NIMH NIH HHS R10 MH056390
6 · The paper itself

Abstract

Mood disorders and suicidal behavior have moderate heritability and familial transmission, and are associated with smaller hippocampal volumes. However, it is unclear whether hippocampal alterations reflect heritable risk or epigenetic effects of childhood adversity, compensatory mechanisms, illness-related changes, or treatment effects. We sought to separate the relationships of hippocampal substructure volumes to mood disorder, suicidal behavior, and risk and resilience to both by examining high familial risk individuals (HR) who have passed the age of greatest risk for psychopathology onset. Structural brain imaging and hippocampal substructure segmentation quantified Cornu Ammonis (CA1-4), dentate gyrus, and subiculum gray matter volumes in healthy volunteers (HV, N = 25) and three groups with one or more relatives reporting early-onset mood disorder and suicide attempt: 1. Unaffected HR (N = 20); 2. HR with lifetime mood disorder and no suicide attempt (HR-MOOD, N = 25); and 3. HR with lifetime mood disorder and a previous suicide attempt (HR-MOOD + SA, N = 18). Findings were tested in an independent cohort not selected for family history (HV, N = 47; MOOD, N = 44; and MOOD + SA, N = 21). Lower CA3 volume was found in HR (vs. HV), consistent with the direction of previously published findings in MOOD+SA (vs. HV and MOOD), suggesting the finding reflects a familial biological risk marker, not illness or treatment-related sequelae, of suicidal behavior and mood disorder. Familial suicide risk may be mediated in part by smaller CA3 volume. The structure may serve as a risk indicator and therapeutic target for suicide prevention strategies in high-risk families.

Indexed as

Mood DisordersSuicidal IdeationHippocampusHumansMagnetic Resonance ImagingRisk FactorsSuicide, AttemptedEarly life adversityFamilial transmissionHeritableHippocampus subfieldsRisk factorsSuicidal behavior

Identifiers

PMID37244064
PMCPMC11448310
OpenAlexW4376638328

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.