ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2023
Change in lipids before onset of dementia, coronary heart disease, and mortality: A 28-year follow-up Whitehall II prospective cohort study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 13 citations in OpenAlex.
- Impact of risk factor burden and vascular bed involvement on dementia risk in individuals with established cardiovascular disease.American journal of preventive cardiology · 2026Article
- LipiDecipher: A Structure-Oriented Analytical Framework for Interpretable Clinical Lipidomics.Metabolites · 2026Article
- Health behavior risk prediction in metabolic syndrome patients: development and validation of an interpretable machine learning model via multisource heterogeneous data integration.BMC medical informatics and decision making · 2026Article
- Lipid profile dynamics and associated cardiovascular disease risk indices in Chinese people living with human immunodeficiency virus receiving antiretroviral therapy.BMC infectious diseases · 2026Article
- Comparison of cognitive decline rates and risk factors between stroke and non - stroke populations: An analysis of data from the China health and retirement longitudinal study (CHARLS).Cerebral circulation - cognition and behavior · 2026Article
- Vascular risk factor variability and cognitive impairment in older adults a community-based retrospective study.Scientific reports · 2025Article
- Integrated plasma and red blood cell membrane lipidomics analysis unveils novel biomarker panel for Alzheimer's disease.Alzheimer's research & therapy · 2025Article
- Optimizing midlife metabolic syndrome thresholds for dementia: a prospective study of two UK population-based cohorts.Alzheimer's research & therapy · 2025Article
- Relationship between serum albumin level and hospitalization duration following percutaneous coronary intervention for acute coronary syndrome.Scientific reports · 2024Article
- Role of cardiovascular health factors in mediating social inequalities in the incidence of dementia in the UK: two prospective, population-based cohort studies.EClinicalMedicine · 2024Article
- Change in lipids before onset of dementia, coronary heart disease, and mortality: A 28-year follow-up Whitehall II prospective cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Association of non-HDL-C and depression: a cross-sectional analysis of the NHANES data.Frontiers in psychiatry · 2023Article
- Blood lipids as accessible biomarkers for early dementia risk screening: Bridging diagnostic gaps in resource-limited settings.Journal of Alzheimer's disease reportsReview
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
introductionThe association of lipids with dementia remains a subject of debate. Using data from 7,672 participants of the Whitehall II prospective cohort study, we examined whether timing of exposure, length of follow-up, or sex modifies this association.
methodsTwelve markers of lipid levels were measured from fasting blood and eight among them a further five times. We performed time-to-event as well as trajectory analyses.
resultsNo associations were observed in men; in women most lipids were associated with the risk of dementia, but only for events occurring after the first 20 years of follow-up. Differences in lipid trajectories in men emerged only in the years immediately before diagnosis whereas in women total cholesterol (TC), LDL-cholesterol (LDL-C), non-HDL-cholesterol (non-HDL-C), TC/HDL-C, and LDL-C/HDL-C were higher in midlife among dementia cases before declining progressively. DISCUSSION: Abnormal lipid levels in midlife seem to be associated with a higher risk of dementia in women.
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