Evidence map›Paper›PMID 37243888›Full record

ReviewInternational journal of hematology2023

Transcriptome sequencing identifies novel EVX fusions involved in transcriptional activation of HOX family genes in pediatric immature T-cell acute lymphoblastic leukemia: two cases reports and a literature review.

Xiao Zhang, Bowen Cui, Yizhen Li, Zhiheng Li, Jiajia Zheng, Xinran Chu, Peifang Xiao, Jun Lu, Zheng Wang, Jiannong Cen and 2 more

Abstract readReviewCase Reports
PubMed Publisher
In one paragraph

Review in International journal of hematology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Xiao ZhangDepartment of Hematology, Jiangsu Children's Hematology and Oncology Center, and the Children's Hospital of Soochow University, Suzhou, 215025, China.
Bowen CuiPediatric Translational Medicine Institute, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Yizhen LiDivision of Pharmaceutical Sciences, Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place MS313, Memphis, TN, 38105, USA.
Zhiheng LiDepartment of Hematology, Jiangsu Children's Hematology and Oncology Center, and the Children's Hospital of Soochow University, Suzhou, 215025, China.
Jiajia ZhengDepartment of Hematology, Jiangsu Children's Hematology and Oncology Center, and the Children's Hospital of Soochow University, Suzhou, 215025, China.
Xinran ChuDepartment of Hematology, Jiangsu Children's Hematology and Oncology Center, and the Children's Hospital of Soochow University, Suzhou, 215025, China.
Peifang XiaoDepartment of Hematology, Jiangsu Children's Hematology and Oncology Center, and the Children's Hospital of Soochow University, Suzhou, 215025, China.
Jun LuDepartment of Hematology, Jiangsu Children's Hematology and Oncology Center, and the Children's Hospital of Soochow University, Suzhou, 215025, China.
Zheng WangJiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, 215000, China.
Jiannong CenJiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, 215000, China.
Yu LiuPediatric Translational Medicine Institute, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. liuyu@scmc.com.cn.
Shaoyan HuDepartment of Hematology, Jiangsu Children's Hematology and Oncology Center, and the Children's Hospital of Soochow University, Suzhou, 215025, China. hushaoyan@suda.edu.cn.ORCID http://orcid.org/0000-0002-5183-2259
Soochow University · CNShanghai Jiao Tong University · CNSt. Jude Children's Research Hospital · US

Funding

Jiangsu Project BE2021654National Natural Science Foundation of China 81970163National Natural Science Foundation of China 82170218Shanghai Key Laboratory of Clinical Molecular Diagnostics for Pediatrics 20dz2260900Suzhou Project GSWS2020039the National Clinical Research Center for Hematological Disorders 2020ZKPB02
6 · The paper itself

Abstract

Driver genomic alterations in pediatric immature T-cell acute lymphoblastic leukemia are not fully known. We report two cases of novel EVX fusions involved in the transcriptional activation of HOX family genes, ETV6::EVX2 and MSI2::EVX1/HOXA13, which activate HOXD and HOXA cluster genes transcription through enhancer hijacking. HOXA and HOXD were the only key transcription factors activated in these cases, which indicates their important roles in leukemogenesis. Our findings elucidate potential drivers for development of T-cell lymphoblastic leukemia, and are valuable for diagnosis and risk stratification of pediatric T-ALL in the era of precision medicine.

Indexed as

Leukemia, T-CellPrecursor T-Cell Lymphoblastic Leukemia-LymphomaChildGenes, HomeoboxHumansRNA-Binding ProteinsT-LymphocytesTranscriptional ActivationTranscriptomeMSI2 protein, humanRNA-Binding ProteinsHOX family genesNovel EVX fusionsPediatric immature T-ALLTranscriptome sequencing

Identifiers

PMID37243888
OpenAlexW4378531131

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.