Evidence map›Paper›PMID 37243865›Full record

ArticleJournal of endocrinological investigation2023

Neuroendocrine response to diclofenac in healthy subjects: a pilot study.

E Varaldo, M Sibilla, F Bioletto, D Cuboni, N Prencipe, C Bona, M Ferrari, F Viglino, L S Aversa, S Grottoli and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 3 countries.

E VaraldoDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, C.So Dogliotti 14, 10126, Turin, Italy.
M SibillaDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, C.So Dogliotti 14, 10126, Turin, Italy. michela.sibilla@unito.it.ORCID http://orcid.org/0009-0005-7205-941X
F BiolettoDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, C.So Dogliotti 14, 10126, Turin, Italy.
D CuboniDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, C.So Dogliotti 14, 10126, Turin, Italy.
N PrencipeDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, C.So Dogliotti 14, 10126, Turin, Italy.
C BonaDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, C.So Dogliotti 14, 10126, Turin, Italy.
M FerrariDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, C.So Dogliotti 14, 10126, Turin, Italy.
F ViglinoDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, C.So Dogliotti 14, 10126, Turin, Italy.
L S AversaDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, C.So Dogliotti 14, 10126, Turin, Italy.
S GrottoliDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, C.So Dogliotti 14, 10126, Turin, Italy.
E GhigoDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, C.So Dogliotti 14, 10126, Turin, Italy.
V GascoDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, C.So Dogliotti 14, 10126, Turin, Italy.
A M BertonDivision of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, C.So Dogliotti 14, 10126, Turin, Italy.
University of Turin · ITDepartment of Medical Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe precise effects of non-steroidal anti-inflammatory drugs on the neuroendocrine hydro-electrolytic regulation are not precisely understood. The aim of this pilot study was to evaluate, in healthy subjects, the neuroendocrine response of the antidiuretic system to intravenous diclofenac infusion.

methodsFor this single-blinded, cross-over study, we recruited 12 healthy subjects (50% women). Test sessions were divided into three observation times (pre-test; test; 48 h post-test), which were repeated equally on two different occasions, with the administration of diclofenac (75 mg in saline solution 0.9% 100 cc) on 1 day, or placebo (saline solution 0.9% 100 cc) on another day. The night before the test the subjects were asked to collect a salivary cortisol and cortisone sample, which was repeated on the night of the procedure session. Serial urine and blood samples were collected on the test day (for osmolality, electrolytes, ACTH, cortisol, copeptin, MR-proADM, MR-proANP; the last three represent more stable and analytically reliable molecules than their respective active peptides). Moreover, the subjects were evaluated with the bioimpedance vector analysis (BIVA) before and after the test. Forty-eight hours after the end of the procedure urine sodium, urine potassium, urine osmolality, serum sodium and copeptin were revaluated together with BIVA.

resultsNo significant changes in circulating hormone levels were observed; anyway, 48 h after diclofenac, BIVA showed a significant water retention (p < 0.00001), especially in extracellular fluid (ECF) (16.47 ± 1.65 vs 15.67 ± 1.84, p < 0.001). Salivary cortisol and cortisone tended to increase only the night after placebo administration (p = 0.054 cortisol; p = 0.021 cortisone).

conclusionDiclofenac resulted in an increased ECF at 48 h, but this phenomenon seems to be associated with a greater renal sensibility to the action of vasopressin rather than with an increase in its secretion. Moreover, a partial inhibitory effect on cortisol secretion can be hypothesized.

Indexed as

CortisoneDiclofenacCross-Over StudiesFemaleHealthy VolunteersHumansHydrocortisoneMalePilot ProjectsSaline SolutionSodiumCortisoneDiclofenacHydrocortisoneSaline SolutionSodiumArginine-vasopressinCopeptinMR-proADMMR-proANPNSAIDsProstaglandins

Identifiers

PMID37243865
PMCPMC10632215
OpenAlexW4378575780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.