Evidence map›Paper›PMID 37243806›Full record

ArticleCurrent medical science2023

Immp2l Mutation Induces Mitochondrial Membrane Depolarization and Complex III Activity Suppression after Middle Cerebral Artery Occlusion in Mice.

Yi Ma, Rui-Min Liang, Ning Ma, Xiao-Juan Mi, Zheng-Yi Cheng, Zi-Jing Zhang, Bai-Song Lu, P Andy Li

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Article in Current medical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Yi Ma *Department of Pathology, School of Basic Medicine, Ningxia Medical University, Yinchuan, 750004, China. mayi_nxmu@163.com.
Rui-Min Liang *Department of Pathology, School of Basic Medicine, Ningxia Medical University, Yinchuan, 750004, China.
Ning MaDepartment of Pathology, School of Basic Medicine, Ningxia Medical University, Yinchuan, 750004, China.
Xiao-Juan MiDepartment of Pathology, School of Basic Medicine, Ningxia Medical University, Yinchuan, 750004, China.
Zheng-Yi ChengDepartment of Pathology, Xi'an No. 3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, 710018, China.
Zi-Jing ZhangDepartment of Anesthesiology, Ningxia Chinese Medicine Research Center, Yinchuan, 750004, China.
Bai-Song LuInstitute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, 27110, USA.
P Andy LiDepartment of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technological Enterprise (BRITE), North Carolina Central University, Durham, 27707, USA. pli@nccu.edu.
Ningxia Medical University · CNNorth Carolina Central University · USNorthwest University · CNWake Forest University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe previously reported that mutations in inner mitochondrial membrane peptidase 2-like (Immp2l) increase infarct volume, enhance superoxide production, and suppress mitochondrial respiration after transient cerebral focal ischemia and reperfusion injury. The present study investigated the impact of heterozygous Immp2l mutation on mitochondria function after ischemia and reperfusion injury in mice.

methodsMice were subjected to middle cerebral artery occlusion for 1 h followed by 0, 1, 5, and 24 h of reperfusion. The effects of Immp2l

resultsImmp2l

conclusionThe adverse impact of Immp2l

Indexed as

Ischemic Attack, TransientReperfusion InjuryAnimalsCaspase 3Electron Transport Complex IIIEndopeptidasesInfarction, Middle Cerebral ArteryMiceMitochondrial MembranesMitochondrial ProteinsMutationCaspase 3Electron Transport Complex IIIEndopeptidasesinner mitochondrial membrane peptidase 2-like protein, mouseMitochondrial Proteinsapoptosiscerebral ischemiainner mitochondrial membrane peptidase 2-likemitochondrial complex IIImitochondrial membrane potential

Identifiers

PMID37243806
OpenAlexW4378438600

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.