Evidence map›Paper›PMID 37243790›Full record

ArticleFunctional & integrative genomics2023

Identification of 12 hub genes associated to the pathogenesis of osteoporosis based on microarray and single-cell RNA sequencing data.

Zhigang Zhou, Zhangheng Huang, Haider Mohammed Khan, Yuheng Liu, Zhen Zhao, Qingquan Kong

Abstract read
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In one paragraph

Article in Functional & integrative genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zhigang ZhouDepartment of Orthopedics Surgery, West China Hospital, Sichuan University, Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Lane, Chengdu, 610041, Sichuan, China.
Zhangheng HuangDepartment of Orthopedics Surgery, West China Hospital, Sichuan University, Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Lane, Chengdu, 610041, Sichuan, China.
Haider Mohammed KhanDepartment of Orthopedics Surgery, West China Hospital, Sichuan University, Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Lane, Chengdu, 610041, Sichuan, China.
Yuheng LiuDepartment of Orthopedics Surgery, West China Hospital, Sichuan University, Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Lane, Chengdu, 610041, Sichuan, China.
Zhen ZhaoDepartment of Orthopedics Surgery, West China Hospital, Sichuan University, Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Lane, Chengdu, 610041, Sichuan, China.
Qingquan KongDepartment of Orthopedics Surgery, West China Hospital, Sichuan University, Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Lane, Chengdu, 610041, Sichuan, China. kqqspine@126.com.
West China Hospital of Sichuan University · CNSichuan University · CN

Funding

Science and technology plan project of Tibet Autonomous Region XZ202201ZY0039G
6 · The paper itself

Abstract

Osteoporosis is a common disease, especially among the elderly. This study aimed to comprehensively examine the roles of immune microenvironment in osteoporosis pathogenesis. Expression profiles of GSE35959, GSE7158, and GSE13850 datasets were used to analyze differential expression and identify hub genes related to immune features. Based on the single-cell RNA sequencing (scRNA-seq) data of an osteoporosis patient, different cell types were classified and the relation between immune environment and osteoporosis was explored. Twelve hub genes significantly associated with immune features were selected and 11 subgroups were defined using scRNA-seq data. The expression of two hub genes (CDKN1A and TEFM) was greatly altered during the transformation from mesenchymal stem cells (MSCs) to osteoblasts. Chemokines and chemokine receptors were differentially enriched in different cell types. CXCL12 was high-expressed in MSCs. This study emphasized that immune microenvironment played a critical role in the pathogenesis of osteoporosis. Chemokines and chemokine receptors can modify cell development and affect the interactions among different cell types, leading to unbalanced bone remodeling.

Indexed as

OsteoporosisAgedCells, CulturedChemokinesHumansReceptors, ChemokineSequence Analysis, RNAChemokinesReceptors, ChemokineBone remodelingChemokinesImmune microenvironmentMesenchymal stromal cellsOsteoblastsOsteoporosis

Identifiers

PMID37243790
OpenAlexW4378531013

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.