Evidence map›Paper›PMID 37243546›Full record

ArticleAnnals of medicine2023

Clinical utility of chromosomal microarray analysis and whole exome sequencing in foetuses with oligohydramnios.

Xiaomei Shi, Hongke Ding, Chen Li, Ling Liu, LiHua Yu, Juan Zhu, Jing Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Prenatal diagnosis of aFrontiers in genetics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xiaomei ShiGenetic Medical Center, Guangdong Women and Children Hospital, Guangzhou, China.
Hongke DingGenetic Medical Center, Guangdong Women and Children Hospital, Guangzhou, China.
Chen LiGenetic Medical Center, Guangdong Women and Children Hospital, Guangzhou, China.
Ling LiuGenetic Medical Center, Guangdong Women and Children Hospital, Guangzhou, China.
LiHua YuGenetic Medical Center, Guangdong Women and Children Hospital, Guangzhou, China.
Juan ZhuGenetic Medical Center, Guangdong Women and Children Hospital, Guangzhou, China.
Jing WuGenetic Medical Center, Guangdong Women and Children Hospital, Guangzhou, China.
Guangdong Province Women and Children Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the clinical utility of chromosomal microarray analysis (CMA) and whole exome sequencing (WES) in foetuses with oligohydramnios.

methodsIn this retrospective study, 126 fetuses with oligohydramnios at our centre from 2018 to 2021 were reviewed. The results of CMA and WES were analysed.

resultsOne hundred and twenty-four cases underwent CMA and 32 cases underwent WES. The detection rate of pathogenic/likely pathogenic (P/LP) copy number variant (CNV) by CMA was 1.6% (2/124). WES revealed P/LP variants in 21.8% (7/32) of the foetuses. Six (85.7%, 6/7) foetuses showed an autosomal recessive inheritance pattern. Three (42.9%, 3/7) variants were involved in the renin-angiotensin-aldosterone system (RAAS), which are the known genetic causes of autosomal recessive renal tubular dysgenesis (ARRTD).

conclusionCMA has low diagnostic utility for oligohydramnios, while WES offers obvious advantages in improving the detection rate. WES should be recommended for fetuses with oligohydramnios.

Indexed as

OligohydramniosExome SequencingFemaleFetusHumansMicroarray AnalysisPregnancyPrenatal DiagnosisRetrospective Studieschromosomal microarray analysisoligohydramniosPrenatal diagnosiswhole exome sequencing

Identifiers

PMID37243546
PMCPMC10228326
OpenAlexW4378575429

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.