Evidence map›Paper›PMID 37243541›Full record

ArticleGenome biology and evolution2023

"Correcting" Gene Trees to be More Like Species Trees Frequently Increases Topological Error.

Zhi Yan, Huw A Ogilvie, Luay Nakhleh

Abstract read
In one paragraph

Article in Genome biology and evolution, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Poplar: a phylogenomics pipeline.Bioinformatics advances · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zhi YanDepartment of Computer Science, Rice University, 6100 Main Street, Houston, TX 77005USA.ORCID 0000-0003-2433-5553
Huw A OgilvieDepartment of Computer Science, Rice University, 6100 Main Street, Houston, TX 77005USA.
Luay NakhlehDepartment of Computer Science, Rice University, 6100 Main Street, Houston, TX 77005USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The evolutionary histories of individual loci in a genome can be estimated independently, but this approach is error-prone due to the limited amount of sequence data available for each gene, which has led to the development of a diverse array of gene tree error correction methods which reduce the distance to the species tree. We investigate the performance of two representatives of these methods: TRACTION and TreeFix. We found that gene tree error correction frequently increases the level of error in gene tree topologies by "correcting" them to be closer to the species tree, even when the true gene and species trees are discordant. We confirm that full Bayesian inference of the gene trees under the multispecies coalescent model is more accurate than independent inference. Future gene tree correction approaches and methods should incorporate an adequately realistic model of evolution instead of relying on oversimplified heuristics.

Indexed as

GenomeModels, GeneticBayes TheoremPhylogenyanomaly zonegene tree error correctiongene tree inferenceincomplete lineage sortingmultispecies coalescent

Identifiers

PMID37243541
PMCPMC10263008

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.