Evidence map›Paper›PMID 37243452›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2023

Mechanistic Computational Modeling of Implantable, Bioresorbable Drug Release Systems.

Patrick A Giolando, Kelsey Hopkins, Barrett F Davis, Nicole Vike, Adib Ahmadzadegan, Arezoo M Ardekani, Pavlos P Vlachos, Joseph V Rispoli, Luis Solorio, Tamara L Kinzer-Ursem

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Patrick A GiolandoWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.ORCID https://orcid.org/0000-0002-0500-0603
Kelsey HopkinsWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.ORCID https://orcid.org/0000-0001-6432-7772
Barrett F DavisWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.ORCID https://orcid.org/0000-0002-3701-1024
Nicole VikeWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.ORCID https://orcid.org/0000-0002-8617-2377
Adib AhmadzadeganSchool of Mechanical Engineering, Purdue University, West Lafayette, IN, 47907, USA.ORCID https://orcid.org/0000-0002-1155-1401
Arezoo M ArdekaniSchool of Mechanical Engineering, Purdue University, West Lafayette, IN, 47907, USA.ORCID https://orcid.org/0000-0003-3301-3193
Pavlos P VlachosWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.ORCID https://orcid.org/0000-0002-8040-9257
Joseph V RispoliWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.
Luis SolorioWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.ORCID https://orcid.org/0000-0003-0135-8728
Tamara L Kinzer-UrsemWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.ORCID https://orcid.org/0000-0001-7343-115X
Purdue University West Lafayette · US

Funding

NRI: Mobile Microrobots for Precision MedicineU01TR004239 · NCATS · PURDUE UNIVERSITY · PI CAPPELLERI, DAVID JOHN, GOERGEN, CRAIG J. · 2022 to 2024
$1.1M
Engineering the Cancer MicroenvironmentR00CA198929 · NCI · PURDUE UNIVERSITY · PI SOLORIO, LUIS · 2017 to 2019
$697k
Prescription Opioid Formulation to Deter Extraction, Injection, Insufflation, and SmokingR21DA048074 · NIDA · PURDUE UNIVERSITY · PI SOLORIO, LUIS · 2019 to 2020
$420k
Removable second-order trap for common-mode current suppression in multi-nuclear MRI cablingR03EB026231 · NIBIB · PURDUE UNIVERSITY · PI RISPOLI, JOSEPH V · 2018 to 2019
$143k
NCATS NIH HHS U01 TR004239NCI NIH HHS R00 CA198929NCI NIH HHS R00CA198929NIBIB NIH HHS R03 EB026231NIBIB NIH HHS R03EB026231NIDA NIH HHS R21 DA048074NIH HHS
6 · The paper itself

Abstract

Implantable, bioresorbable drug delivery systems offer an alternative to current drug administration techniques; allowing for patient-tailored drug dosage, while also increasing patient compliance. Mechanistic mathematical modeling allows for the acceleration of the design of the release systems, and for prediction of physical anomalies that are not intuitive and may otherwise elude discovery. This study investigates short-term drug release as a function of water-mediated polymer phase inversion into a solid depot within hours to days, as well as long-term hydrolysis-mediated degradation and erosion of the implant over the next few weeks. Finite difference methods are used to model spatial and temporal changes in polymer phase inversion, solidification, and hydrolysis. Modeling reveals the impact of non-uniform drug distribution, production and transport of H

Indexed as

Absorbable ImplantsDrug Delivery SystemsComputer SimulationDrug LiberationHumansMicrospheresPolymersWaterPolymersWaterbiodegradabledrug deliveryin situ forming implantmathematical modelingmicrospheres

Identifiers

PMID37243452
PMCPMC10697660
OpenAlexW4378515356

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.