Evidence map›Paper›PMID 37243289›Full record

ArticleViruses2023

β-Glucan Induces Training Immunity to Promote Antiviral Activity by Activating TBK1.

Guolei Wang, Zhiqiang Li, Mingfu Tian, Xianghua Cui, Jun'e Ma, Siyu Liu, Chenglin Ye, Li Yuan, Muhammad Suhaib Qudus, Uzair Afaq and 3 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
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  10. Recent Advances of Trained immunity in Macrophages.International journal of biological sciences · 2025
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Guolei WangDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Zhiqiang LiDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Mingfu TianState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Xianghua CuiDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Jun'e MaDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Siyu LiuState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Chenglin YeDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Li YuanDepartment of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan 430060, China.
Muhammad Suhaib QudusState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Uzair AfaqState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Kailang WuState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Xinghui LiuDepartment of Clinical Laboratory, Shanghai Gongli Hospital, The Second Military Medical University, Pudong New Area, Shanghai 200135, China.
Chengliang ZhuDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Wuhan University · CNRenmin Hospital of Wuhan University · CNSecond Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many studies have shown that β-glucan induces a trained immune phenotype in innate immune cells to defend against bacterial and fungal infections. The specific mechanism involves cellular metabolism and epigenetic reprogramming. However, it is unclear whether β-glucan plays a role in antiviral infection. Therefore, this study investigated the role of trained immunity induced by

Indexed as

Signal TransductionAnimalsImmunity, InnateInterferon-betaMicePhosphorylationProtein Serine-Threonine KinasesInterferon-betaProtein Serine-Threonine KinasesTbk1 protein, mouseinnate immunityTBK1trained immunityubiquitination

Identifiers

PMID37243289
PMCPMC10221698
OpenAlexW4377291808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.