ArticleViruses2023
Genetic Analysis of Dengue Virus in Severe and Non-Severe Cases in Dhaka, Bangladesh, in 2018-2022.
Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Epidemiological Characteristics of Dengue Infection in Bangladesh: A Systematic Review.International journal of environmental research and public health · 2026Pooled it
- Evolving epidemiology, clinical features, and genotyping of dengue outbreaks in Bangladesh, 2000-2024: a systematic review.Frontiers in microbiology · 2024Pooled it
- Clinical and epidemiological characteristics of the 2025 dengue outbreak in Bangladesh.PLoS neglected tropical diseases · 2026Observational
- Identification of Ligand-Responsive RNA G-Quadruplexes in the 3' UTRs of Dengue Virus Serotypes.Biomolecules · 2026Article
- Review
- Epitope dynamics and antigenic shifts in dengue virus serotype 2 cosmopolitan genotype with structural changes in Bangladesh from 2017 to 2023.Scientific reports · 2026Article
- Article
- An Improved Dengue Virus Serotype-Specific Non-Structural Protein 1 Capture Immunochromatography Method with Reduced Sample Volume.Biosensors · 2025Article
- Dominance of DENV-1 and Flavivirus Serological Cross-Reactivity During the 2016 Dengue Outbreak in Vietnam.Journal of medical virology · 2025Article
- Entomo-Virological Surveillance and Genomic Insights into DENV-2 Genotype III Circulation in Rural Esmeraldas, Ecuador.Pathogens (Basel, Switzerland) · 2025Article
- Clinical and epidemiological characteristics of the dengue outbreak of 2024: a multicenter observation from Bangladesh.Tropical medicine and health · 2025Article
- Dengue Investigation Research in Bangladesh: Insights From a Scoping Review.Health science reports · 2025Review
- Molecular epidemiology of circulating dengue serotypes in Dhaka, Bangladesh: 2023 outbreak.IJID regions · 2025Article
- Genomic Characterization of Circulating Dengue Virus, Ethiopia, 2022-2023.Emerging infectious diseases · 2025Article
- MCP-1 Reduction by L-SIGN Expression in Dengue Virus-Infected Liver Endothelial Cells.Viruses · 2025Article
- Epidemiology and Genotype Dynamics of Dengue in Hospitalized Patients in Northern Vietnam Between 2020 and 2022.Open forum infectious diseases · 2025Article
- Dengue Virus Serotype 2 Cosmopolitan C Genotype Reemerges With a New Strain in Southwest Region of Bangladesh.Transboundary and emerging diseases · 2025Article
- Resurgence of Dengue Virus Serotype 2: Findings from the 2023 Bangladesh Outbreak.The American journal of tropical medicine and hygiene · 2024Article
- Bangladesh records persistently increased number of dengue deaths in recent years: Dissecting the shortcomings and means to resolve.IJID regions · 2024Article
- Unraveling Dengue Virus Diversity in Asia: An Epidemiological Study through Genetic Sequences and Phylogenetic Analysis.Viruses · 2024Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue virus (DENV) infections have unpredictable clinical outcomes, ranging from asymptomatic or minor febrile illness to severe and fatal disease. The severity of dengue infection is at least partly related to the replacement of circulating DENV serotypes and/or genotypes. To describe clinical profiles of patients and the viral sequence diversity corresponding to non-severe and severe cases, we collected patient samples from 2018 to 2022 at Evercare Hospital Dhaka, Bangladesh. Serotyping of 495 cases and sequencing of 179 cases showed that the dominant serotype of DENV shifted from DENV2 in 2017 and 2018 to DENV3 in 2019. DENV3 persisted as the only representative serotype until 2022. Co-circulation of clades B and C of the DENV2 cosmopolitan genotype in 2017 was replaced by circulation of clade C alone in 2018 with all clones disappearing thereafter. DENV3 genotype I was first detected in 2017 and was the only genotype in circulation until 2022. We observed a high incidence of severe cases in 2019 when the DENV3 genotype I became the only virus in circulation. Phylogenetic analysis revealed clusters of severe cases in several different subclades of DENV3 genotype I. Thus, these serotype and genotype changes in DENV may explain the large dengue outbreaks and increased severity of the disease in 2019.
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