Evidence map›Paper›PMID 37243218›Full record

ArticleViruses2023

Booster Dose of SARS-CoV-2 mRNA Vaccine in Kidney Transplanted Patients Induces Wuhan-Hu-1 Specific Neutralizing Antibodies and T Cell Activation but Lower Response against Omicron Variant.

Andrea Del Mastro, Stefania Picascia, Luciana D'Apice, Maria Trovato, Pasquale Barba, Immacolata Di Biase, Sebastiano Di Biase, Marco Laccetti, Antonello Belli, Gerardino Amato and 6 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Detection of Gliadin-Activated CD4Journal of cellular and molecular medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Andrea Del MastroAORN A. Cardarelli-Internal Medicine Division 1-Immunology Unit, 80131 Naples, Italy.
Stefania PicasciaInstitute of Biochemistry and Cell Biology, Italian National Council of Research, 80131 Naples, Italy.ORCID 0000-0003-1080-9391
Luciana D'ApiceInstitute of Biochemistry and Cell Biology, Italian National Council of Research, 80131 Naples, Italy.ORCID 0000-0002-6513-2237
Maria TrovatoInstitute of Biochemistry and Cell Biology, Italian National Council of Research, 80131 Naples, Italy.ORCID 0000-0002-3831-6073
Pasquale BarbaInstitute of Biochemistry and Cell Biology, Italian National Council of Research, 80131 Naples, Italy.
Immacolata Di BiaseMeriGen Diagnostic&C, SAS, 80131 Naples, Italy.
Sebastiano Di BiaseMeriGen Diagnostic&C, SAS, 80131 Naples, Italy.
Marco LaccettiAORN A. Cardarelli-Internal Medicine Division 1-Immunology Unit, 80131 Naples, Italy.
Antonello BelliAORN A. Cardarelli-Clinical Pathology Division, 80131 Naples, Italy.
Gerardino AmatoAORN A. Cardarelli-Clinical Pathology Division, 80131 Naples, Italy.
Potito Di MuroAORN A. Cardarelli-Nephrology and Dialysis Unit, 80131 Naples, Italy.
Olga CredendinoAORN A. Cardarelli-Nephrology and Dialysis Unit, 80131 Naples, Italy.
Alessandra PicardiAORN A. Cardarelli-Molecular Biology Laboratory-Hematology and HSC Transplantation Unit, 80131 Naples, Italy.ORCID 0000-0002-0136-7686
Piergiuseppe De BerardinisInstitute of Biochemistry and Cell Biology, Italian National Council of Research, 80131 Naples, Italy.
Giovanna Del PozzoInstitute of Genetics and Biophysics, Italian National Council of Research, 80131 Naples, Italy.ORCID 0000-0001-8937-9018
Carmen GianfraniInstitute of Biochemistry and Cell Biology, Italian National Council of Research, 80131 Naples, Italy.
Ospedale Antonio Cardarelli · ITInstitute of Genetics and Biophysics · IT

Funding

Large Scale T Cell Epitope Discovery:Global identification of epitopes derived from Zika (ZIKV), Chikungunya (CHIKV) viruses following natural infection and vaccination75N93019C00065 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI MITCHELL, MAYA · 2019 to 2023
$7.3M
NIAID NIH HHS 75N93019C00065
6 · The paper itself

Abstract

Kidney transplanted recipients (KTR) are at high risk of severe SARS-CoV-2 infection due to immunosuppressive therapy. Although several studies reported antibody production in KTR after vaccination, data related to immunity to the Omicron (B.1.1.529) variant are sparse. Herein, we analyzed anti-SARS-CoV-2 immune response in seven KTR and eight healthy controls after the second and third dose of the mRNA vaccine (BNT162b2). A significant increase in neutralizing antibody (nAb) titers were detected against pseudoviruses expressing the Wuhan-Hu-1 spike (S) protein after the third dose in both groups, although nAbs in KTR were lower than controls. nAbs against pseudoviruses expressing the Omicron S protein were low in both groups, with no increase after the 3rd dose in KTR. Reactivity of CD4

Indexed as

COVID-19COVID-19 VaccinesAntibodies, NeutralizingAntibodies, ViralBNT162 VaccineHumansKidneymRNA VaccinesSARS-CoV-2Antibodies, NeutralizingAntibodies, ViralBNT162 VaccineCOVID-19 VaccinesmRNA VaccinesCOVID-19immunitykidney transplanted patientsmRNA vaccineneutralizing antibodiesOmicron variantSARS-CoV-2T cellstransplantation

Identifiers

PMID37243218
PMCPMC10224015
OpenAlexW4378516319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.