Evidence map›Paper›PMID 37243121›Full record

ArticleViruses2023

Construction of a Hantaan Virus Phage Antibody Library and Screening for Potential Neutralizing Activity.

Zhuo Li, Huiyuan Zhang, Xiaxia Yu, Yusi Zhang, Lihua Chen

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Generation and Characterization of the Human Anti-HTNV Antibody KJJ4.International journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Zhuo LiDepartment of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China.
Huiyuan ZhangDepartment of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China.ORCID 0000-0002-5557-3645
Xiaxia YuDepartment of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China.
Yusi ZhangDepartment of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China.ORCID 0000-0003-4272-857X
Lihua ChenDepartment of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China.
Air Force Medical University · CNYan'an University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

China is one of the main epidemic areas for hemorrhagic fever with renal syndrome (HFRS). Currently, there is no human antibody specific to Hantaan virus (HTNV) for the emergency prevention and treatment of HFRS. To prepare human antibodies with neutralizing activity, we established an anti-HTNV phage antibody library using phage display technology by transforming peripheral blood mononuclear cells (PBMCs) of patients with HFRS into B lymphoblastoid cell lines (BLCLs) and extracting cDNA from BLCLs that secreted neutralizing antibodies. Based on the phage antibody library, we screened HTNV-specific Fab antibodies with neutralizing activities. Our study provides a potential way forward for the emergency prevention of HTNV and specific treatment of HFRS.

Indexed as

Hantaan virusHemorrhagic Fever with Renal SyndromeAntibodies, NeutralizingAntibodies, ViralHumansLeukocytes, MononuclearAntibodies, NeutralizingAntibodies, ViralHantaan virus (HTNV)neutralizing antibodies (NAb)phage antibody library

Identifiers

PMID37243121
PMCPMC10221454
OpenAlexW4366814638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.