Evidence map›Paper›PMID 37243070›Full record

ArticleVaccines2023

Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode

Johanna F Scheunemann, Frederic Risch, Julia J Reichwald, Benjamin Lenz, Anna-Lena Neumann, Stephan Garbe, Stefan J Frohberger, Marianne Koschel, Jesuthas Ajendra, Maximilian Rothe and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Johanna F ScheunemannInstitute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53127 Bonn, Germany.
Frederic RischInstitute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53127 Bonn, Germany.
Julia J ReichwaldInstitute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0002-9255-6780
Benjamin LenzInstitute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0001-9991-5435
Anna-Lena NeumannInstitute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53127 Bonn, Germany.
Stephan GarbeClinic for Radiotherapy and Radiation Oncology, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0003-3430-4590
Stefan J FrohbergerInstitute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53127 Bonn, Germany.
Marianne KoschelInstitute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53127 Bonn, Germany.
Jesuthas AjendraInstitute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0002-9256-5396
Maximilian RotheInstitute for Innate Immunity, University Hospital Bonn, 53127 Bonn, Germany.
Eicke LatzInstitute for Innate Immunity, University Hospital Bonn, 53127 Bonn, Germany.
Christoph CochInstitute for Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, 53127 Bonn, Germany.
Gunther HartmannInstitute for Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, 53127 Bonn, Germany.
Beatrix SchumakInstitute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53127 Bonn, Germany.
Achim HoeraufInstitute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53127 Bonn, Germany.
Marc P HübnerInstitute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53127 Bonn, Germany.
University Hospital Bonn · DE

Funding

BONFOR 2017-5-02, 2018-7-01, 2018-7-02, 2019-7-01, 2019-7-02, and 2020-7-03Deutsche Forschungsgemeinschaft Germany's Excellence Strategy EXC 1023Deutsche Forschungsgemeinschaft Germany's Excellence Strategy - EXC2151 - 390873048German Center for Infection Research TTU 09.701Jürgen Manchot Stiftung NA
6 · The paper itself

Abstract

More than two-hundred-million people are infected with filariae worldwide. However, there is no vaccine available that confers long-lasting protection against filarial infections. Previous studies indicated that vaccination with irradiated infective L3 larvae reduces the worm load. This present study investigated whether the additional activation of cytosolic nucleic acid receptors as an adjuvant improves the efficacy of vaccination with irradiated L3 larvae of the rodent filaria

Indexed as

3pRNAfilariaehelminthLitomosoides sigmodontisnucleic acid receptorpoly(I:C)vaccination

Identifiers

PMID37243070
PMCPMC10223226
OpenAlexW4376115038

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.