Evidence map›Paper›PMID 37242992›Full record

ArticleVaccines2023

Assessment of Immune Responses to Rabies Vaccination in Free-Ranging Dogs in Bengaluru, India.

Vinay Chavan Prakash Rao, Sharada Ramakrishnaiah, Shrikrishna Isloor, Rathnamma Doddamane, Dilip Lakshman, Manjunath Shinde Sundar Rao Maralavadi, Avinash Bhat, Balaji Chandrashekar, Krithiga Natesan, Ganesh Kondabattula and 1 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Vinay Chavan Prakash RaoKVAFSU-CVA Rabies Diagnostic Laboratory, WOAH Reference Laboratory for Rabies, Department of Veterinary Microbiology, Veterinary College, KarnatakaVeterinary, Animal and Fisheries Sciences University (KVAFSU), Bengaluru 560024, India.
Sharada RamakrishnaiahKVAFSU-CVA Rabies Diagnostic Laboratory, WOAH Reference Laboratory for Rabies, Department of Veterinary Microbiology, Veterinary College, KarnatakaVeterinary, Animal and Fisheries Sciences University (KVAFSU), Bengaluru 560024, India.
Shrikrishna IsloorKVAFSU-CVA Rabies Diagnostic Laboratory, WOAH Reference Laboratory for Rabies, Department of Veterinary Microbiology, Veterinary College, KarnatakaVeterinary, Animal and Fisheries Sciences University (KVAFSU), Bengaluru 560024, India.
Rathnamma DoddamaneKVAFSU-CVA Rabies Diagnostic Laboratory, WOAH Reference Laboratory for Rabies, Department of Veterinary Microbiology, Veterinary College, KarnatakaVeterinary, Animal and Fisheries Sciences University (KVAFSU), Bengaluru 560024, India.
Dilip LakshmanKVAFSU-CVA Rabies Diagnostic Laboratory, WOAH Reference Laboratory for Rabies, Department of Veterinary Microbiology, Veterinary College, KarnatakaVeterinary, Animal and Fisheries Sciences University (KVAFSU), Bengaluru 560024, India.
Manjunath Shinde Sundar Rao MaralavadiBruhat Bengaluru Mahanagara Palike (BBMP), Bengaluru 560002, India.
Avinash BhatTrouw Nutrition India Pvt. Ltd., Hyderabad 500032, India.
Balaji ChandrashekarProject Lead, Mission Rabies, Bengaluru 560072, India.
Krithiga NatesanKVAFSU-CVA Rabies Diagnostic Laboratory, WOAH Reference Laboratory for Rabies, Department of Veterinary Microbiology, Veterinary College, KarnatakaVeterinary, Animal and Fisheries Sciences University (KVAFSU), Bengaluru 560024, India.
Ganesh KondabattulaICAR-Indian Veterinary Research Institute, Bengaluru 560024, India.ORCID 0000-0002-2305-1797
Nagendra R HegdeNational Institute of Animal Biotechnology, Hyderabad 500032, India.
Karnataka Veterinary Animal and Fisheries Sciences University · INIndian Veterinary Research Institute · INNational Institute of Animal Biotechnology · INRamakrishna Mission Vidyamandira · IN

Funding

National Centre for Disease Control, Ministry of Health and Family Welfare, Government of India ISC/570812/2018/DZDP-NCDC((Pt2) dated 05.11.2019
6 · The paper itself

Abstract

Rabies is a fatal encephalomyelitis mainly transmitted to humans and other animals by rabid dog bites. Hence, vaccination programs are being instituted for the control of rabies in dogs. Though stray dogs have been vaccinated for years under various programs initiated for control of the disease, the effectiveness of these programs can be ascertained only by assessing the immunity of these dogs. With this in view, a study was conducted to assess the effectiveness of the ongoing mass dog vaccination (MDV) program by the Bengaluru City Municipal Corporation, Bengaluru, India. Whole blood and serum samples (n = 260) from vaccinated stray dogs in 26 wards of 8 corporation zones were tested by rapid fluorescent focus inhibition test (RFFIT) as well as an in-house quantitative indirect enzyme-linked immunosorbent assay (iELISA) for a humoral response and by interferon-gamma (IFN-γ) ELISA for a cellular response. As determined by the cut-off value of 0.5 IU/mL of serum, 71% and 87% of the samples from vaccinated dogs revealed adequate levels of antibodies presumed to confer protection by RFFIT and iELISA, respectively. The sensitivity and specificity of the iELISA were 100% and 63.3%, respectively. The IFN-γ ELISA revealed adequate cellular response in 50% of the samples. The quantitative iELISA was found to be useful in large-scale seromonitoring of MDV programs to aid in the elimination of dog-mediated rabies.

Indexed as

immune responserabiesvaccination

Identifiers

PMID37242992
PMCPMC10224170
OpenAlexW4366834074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.