Evidence map›Paper›PMID 37242822›Full record

ArticlePolymers2023

Enhancing Pullulan Soft Capsules with a Mixture of Glycerol and Sorbitol Plasticizers: A Multi-Dimensional Study.

Kecheng Zhou, Yucheng Yang, Bingde Zheng, Qiqi Yu, Yayan Huang, Na Zhang, Shriram Mourougane Rama, Xueqin Zhang, Jing Ye, Meitian Xiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kecheng ZhouCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, China.
Yucheng YangCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, China.ORCID 0000-0001-8817-1741
Bingde ZhengCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, China.ORCID 0000-0001-9548-1457
Qiqi YuCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, China.
Yayan HuangCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, China.
Na ZhangCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, China.
Shriram Mourougane RamaDepartment of Chemical Engineering and Chemistry, Eindhoven University of Technology, Het Kranenveld (Bldg 14-Helix), 5600 MB Eindhoven, The Netherlands.
Xueqin ZhangCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, China.
Jing YeCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, China.
Meitian XiaoCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, China.

Funding

Fund Project the Foreign Cooperation Project of Fujian Province 2020I0018, 2021I0016the Fujian Province Marine Economic Development Special FJHJG-L-2022-6The Industry-university-research collaboration project of Xiamen 2022CXY02010the Major Special Topic of Science and Technology of Fujian Province 2020NZ012013the National Nature Science Foundation of China 81703390, 22078120
6 · The paper itself

Abstract

The plasticizer is crucial in the plant-based soft capsule. However, meeting the quality requirements of these capsules with a single plasticizer is challenging. To address this issue, this study first investigated the impact of a plasticizer mixture containing sorbitol and glycerol in varying mass ratios and the performance of the pullulan soft film and capsule. The multiscale analysis demonstrates that the plasticizer mixture exhibits superior effectiveness in enhancing the performance of the pullulan film/capsule compared to a single plasticizer. Furthermore, thermogravimetric analysis, Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy indicate that the plasticizer mixture enhances the compatibility and thermal stability of the pullulan films without altering their chemical composition. Among the different mass ratios examined, a 15:15 ratio of sorbitol to glycerol (S/G) is identified as the most optimal, leading to superior physicochemical properties and meeting the requirements for brittleness and disintegration time set by the Chinese Pharmacopoeia. This study provides significant insights into the effect of the plasticizer mixture on the performance of pullulan soft capsules and offers a promising application formula for future use.

Indexed as

glycerolplant polysaccharideplasticizer mixturesoft capsulesorbitol

Identifiers

PMID37242822
PMCPMC10224083

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.