Evidence map›Paper›PMID 37242812›Full record

ArticlePolymers2023

Engineered Shellac Beads-on-the-String Fibers Using Triaxial Electrospinning for Improved Colon-Targeted Drug Delivery.

Yaoyao Yang, Wei Chen, Menglong Wang, Jiachen Shen, Zheng Tang, Yongming Qin, Deng-Guang Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yaoyao YangSchool of Materials & Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
Wei ChenSchool of Materials & Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
Menglong WangSchool of Materials & Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.ORCID 0000-0001-9112-4700
Jiachen ShenSchool of Materials & Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
Zheng TangSchool of Materials & Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
Yongming QinSchool of Materials & Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
Deng-Guang YuSchool of Materials & Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.ORCID 0000-0001-7825-4498

Funding

National Natural Science Foundation of China No. 51803121Undergraduate Innovation and Entrepreneurship Training Program No. SH2022244
6 · The paper itself

Abstract

Colon-targeted drug delivery is gradually attracting attention because it can effectively treat colon diseases. Furthermore, electrospun fibers have great potential application value in the field of drug delivery because of their unique external shape and internal structure. In this study, a core layer of hydrophilic polyethylene oxide (PEO) and the anti-colon-cancer drug curcumin (CUR), a middle layer of ethanol, and a sheath layer of the natural pH-sensitive biomaterial shellac were used in a modified triaxial electrospinning process to prepare beads-on-the-string (BOTS) microfibers. A series of characterizations were carried out on the obtained fibers to verify the process-shape/structure-application relationship. The results of scanning electron microscopy and transmission electron microscopy indicated a BOTS shape and core-sheath structure. X-ray diffraction results indicated that the drug in the fibers was in an amorphous form. Infrared spectroscopy revealed the good compatibility of the components in the fibers. In vitro drug release revealed that the BOTS microfibers provide colon-targeted drug delivery and zero-order drug release. Compared to linear cylindrical microfibers, the obtained BOTS microfibers can prevent the leakage of drugs in simulated gastric fluid, and they provide zero-order release in simulated intestinal fluid because the beads in BOTS microfibers can act as drug reservoirs.

Indexed as

beads-on-the-stringcolon-targeted drug deliverycore–sheath structuremodified triaxial electrospinningzero-order release

Identifiers

PMID37242812
PMCPMC10221814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.