Evidence map›Paper›PMID 37242741›Full record

ReviewPharmaceutics2023

Current Trends in Gelatin-Based Drug Delivery Systems.

Francesca Milano, Annalia Masi, Marta Madaghiele, Alessandro Sannino, Luca Salvatore, Nunzia Gallo

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
17.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 133 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Francesca MilanoDepartment of Engineering for Innovation, University of Salento, Via Monteroni, 73100 Lecce, Italy.
Annalia MasiDepartment of Engineering for Innovation, University of Salento, Via Monteroni, 73100 Lecce, Italy.
Marta MadaghieleDepartment of Engineering for Innovation, University of Salento, Via Monteroni, 73100 Lecce, Italy.ORCID 0000-0003-3039-9107
Alessandro SanninoDepartment of Engineering for Innovation, University of Salento, Via Monteroni, 73100 Lecce, Italy.
Luca SalvatoreDepartment of Engineering for Innovation, University of Salento, Via Monteroni, 73100 Lecce, Italy.ORCID 0000-0001-6747-2473
Nunzia GalloDepartment of Engineering for Innovation, University of Salento, Via Monteroni, 73100 Lecce, Italy.ORCID 0000-0003-1810-7917
University of Salento · IT

Funding

Regione Puglia B89J20002390009
6 · The paper itself

Abstract

Gelatin is a highly versatile natural polymer, which is widely used in healthcare-related sectors due to its advantageous properties, such as biocompatibility, biodegradability, low-cost, and the availability of exposed chemical groups. In the biomedical field, gelatin is used also as a biomaterial for the development of drug delivery systems (DDSs) due to its applicability to several synthesis techniques. In this review, after a brief overview of its chemical and physical properties, the focus is placed on the commonly used techniques for the development of gelatin-based micro- or nano-sized DDSs. We highlight the potential of gelatin as a carrier of many types of bioactive compounds and its ability to tune and control select drugs' release kinetics. The desolvation, nanoprecipitation, coacervation, emulsion, electrospray, and spray drying techniques are described from a methodological and mechanistic point of view, with a careful analysis of the effects of the main variable parameters on the DDSs' properties. Lastly, the outcomes of preclinical and clinical studies involving gelatin-based DDSs are thoroughly discussed.

Indexed as

clinical studiesdrug delivery systemsgelatinmicroparticlesnanoparticles

Identifiers

PMID37242741
PMCPMC10221778
OpenAlexW4376956787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.