Evidence map›Paper›PMID 37242706›Full record

ArticlePharmaceutics2023

Transdermal Delivery of α-Aminophosphonates as Semisolid Formulations-An In Vitro-Ex Vivo Study.

Dorottya Kocsis, Petra Regina Varga, Rusul Keshwan, Mina Nader, Miléna Lengyel, Pál Szabó, István Antal, Károly Kánai, György Keglevich, Franciska Erdő

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Dorottya KocsisFaculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter u. 50a, H-1083 Budapest, Hungary.ORCID 0000-0001-7908-3248
Petra Regina VargaDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1521 Budapest, Hungary.
Rusul KeshwanFaculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter u. 50a, H-1083 Budapest, Hungary.
Mina NaderFaculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter u. 50a, H-1083 Budapest, Hungary.
Miléna LengyelDepartment of Pharmaceutics, Semmelweis University, H-1092 Budapest, Hungary.ORCID 0000-0001-8865-054X
Pál SzabóCentre for Structural Study, Research Centre for Natural Sciences, H-1117 Budapest, Hungary.
István AntalDepartment of Pharmaceutics, Semmelweis University, H-1092 Budapest, Hungary.ORCID 0000-0002-5434-201X
Károly KánaiDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1521 Budapest, Hungary.
György KeglevichDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1521 Budapest, Hungary.ORCID 0000-0002-5366-472X
Franciska ErdőFaculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter u. 50a, H-1083 Budapest, Hungary.ORCID 0000-0001-6265-3777
Pázmány Péter Catholic University · HUBudapest University of Technology and Economics · HUSemmelweis University · HUHUN-REN Research Centre for Natural Sciences · HU

Funding

National Research, Development, and Innovation Fund of Hungary ÚNKP-22-3National Research, Development, and Innovation Fund of Hungary, K134318National Research, Development, and Innovation Fund of Hungary, TKP2021-EGA-42
6 · The paper itself

Abstract

α-Aminophosphonates are organophosphorus compounds with an obvious similarity with α-amino acids. Owing to their biological and pharmacological characteristics, they have attracted the attention of many medicinal chemists. α-Aminophosphonates are known to exhibit antiviral, antitumor, antimicrobial, antioxidant and antibacterial activities, which can all be important in pathological dermatological conditions. However, their ADMET properties are not well studied. The aim of the current study was to provide preliminary information about the skin penetration of three preselected α-aminophosphonates when applying them as topical cream formulations in static and dynamic diffusion chambers. The results indicate that aminophosphonate

Indexed as

droplet size distributionrheologyskin-on-a-chiptopical formulationtransdermal penetrationα-aminophosphonates

Identifiers

PMID37242706
PMCPMC10220917
OpenAlexW4378516551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.