Evidence map›Paper›PMID 37242678›Full record

ArticlePharmaceutics2023

Repurposing Disulfiram as an Antifungal Agent: Development of a New Disulfiram Vaginal Mucoadhesive Gel.

Maria Lajarin-Reinares, Iria Naveira-Souto, Mireia Mallandrich, Joaquim Suñer-Carbó, Montserrat Llagostera Casas, Maria Angels Calvo, Francisco Fernandez-Campos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Maria Lajarin-ReinaresDepartment of Genetics and Microbiology, Campus Microbiology Unit, Autonomous University of Barcelona, 08193 Bellaterra, Spain.ORCID 0000-0002-4080-3516
Iria Naveira-SoutoR & D Development, Reig Jofre Laboratories, 08970 Sant Joan Despí, Spain.ORCID 0009-0000-5026-1311
Mireia MallandrichDepartment of Pharmacy and Pharmaceutical Technology and Physical Chemistry, School of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0001-9316-8459
Joaquim Suñer-CarbóDepartment of Pharmacy and Pharmaceutical Technology and Physical Chemistry, School of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-9238-187X
Montserrat Llagostera CasasDepartment of Genetics and Microbiology, Campus Microbiology Unit, Autonomous University of Barcelona, 08193 Bellaterra, Spain.
Maria Angels CalvoDepartment of Animal Health and Anatomy, Faculty of Veterinary, Autonomous University of Barcelona, 08193 Bellaterra, Spain.
Francisco Fernandez-CamposR & D Department, Labiana Pharmaceuticals, 08757 Corbera Llobregat, Spain.ORCID 0000-0001-8224-2932
Universitat Autònoma de Barcelona · ESUniversitat de Barcelona · ESReig Jofre (Spain) · ES

Funding

Government of Catalonia 2020 DI 97
6 · The paper itself

Abstract

Alternative formulations need to be developed to improve the efficacy of treatments administered via the vaginal route. Mucoadhesive gels with disulfiram, a molecule that was originally approved as an antialcoholism drug, offer an attractive alternative to treat vaginal candidiasis. The aim of the current study was to develop and optimize a mucoadhesive drug delivery system for the local administration of disulfiram. Such formulations were composed of polyethylene glycol and carrageenan to improve the mucoadhesive and mechanical properties and to prolong the residence time in the vaginal cavity. Microdilution susceptibility testing showed that these gels had antifungal activity against

Indexed as

ATP-binding cassetteCandida spp.disulfirammucoadhesionresistantvaginitis

Identifiers

PMID37242678
PMCPMC10223105
OpenAlexW4378516872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.