Evidence map›Paper›PMID 37242669›Full record

ReviewPharmaceutics2023

Smart Design of Nanostructures for Boosting Tumor Immunogenicity in Cancer Immunotherapy.

Bohan Yin, Wai-Ki Wong, Yip-Ming Ng, Mo Yang, Franco King-Chi Leung, Dexter Siu-Hong Wong

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Targeted EGFR Nanotherapy in Non-Small Cell Lung Cancer.Journal of functional biomaterials · 2023
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Bohan YinDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong 999077, China.ORCID 0000-0002-3814-470X
Wai-Ki WongState Key Laboratory for Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong 999077, China.
Yip-Ming NgDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong 999077, China.
Mo YangDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong 999077, China.ORCID 0000-0002-3863-8187
Franco King-Chi LeungState Key Laboratory for Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong 999077, China.
Dexter Siu-Hong WongDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong 999077, China.ORCID 0000-0001-7920-4599
Hong Kong Polytechnic University · HK

Funding

Croucher Foundation Croucher Innovation Award-2021Guangdong-Hong Kong Technology Cooperation Funding Scheme GHP/032/20SZGuangdong-Hong Kong Technology Cooperation Funding Scheme SGDX20201103095404018Hong Kong Polytechnic University 1-BD8QHong Kong Polytechnic University 1-W08AHong Kong Polytechnic University 1-ZVRYHong Kong Polytechnic University 1-ZVSTHong Kong Polytechnic University 1-ZVVQHong Kong Polytechnic University Shenzhen Institute Bai Cheng Bai Yuan Fund I2022A002PolyU Seed Fund Project of RISports 1-CD5PPolyU Seed Fund Project of RISports 1-CD6JResearch Grants Council (RGC) of Hong Kong Collaborative Research Grant C5078-21EFResearch Grants Council (RGC) of Hong Kong General Research Grant PolyU 15216622Research Grants Council (RGC) of Hong Kong General Research Grant PolyU 15217621Shenzhen Science and Technology Program-Basic Research Scheme JCYJ20220531090808020
6 · The paper itself

Abstract

Although tumor immunotherapy has emerged as a promising therapeutic method for oncology, it encounters several limitations, especially concerning low response rates and potential off-targets that elicit side effects. Furthermore, tumor immunogenicity is the critical factor that predicts the success rate of immunotherapy, which can be boosted by the application of nanotechnology. Herein, we introduce the current approach of cancer immunotherapy and its challenges and the general methods to enhance tumor immunogenicity. Importantly, this review highlights the integration of anticancer chemo/immuno-based drugs with multifunctional nanomedicines that possess imaging modality to determine tumor location and can respond to stimuli, such as light, pH, magnetic field, or metabolic changes, to trigger chemotherapy, phototherapy, radiotherapy, or catalytic therapy to upregulate tumor immunogenicity. This promotion rouses immunological memory, such as enhanced immunogenic cell death, promoted maturation of dendritic cells, and activation of tumor-specific T cells against cancer. Finally, we express the related challenges and personal perspectives of bioengineered nanomaterials for future cancer immunotherapy.

Indexed as

cancer immunotherapycontrolled releasesmart responsive materialssynergistic therapy

Identifiers

PMID37242669
PMCPMC10221856
OpenAlexW4375844475

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.