Evidence map›Paper›PMID 37242587›Full record

ArticlePharmaceutics2023

Development of Copper Complexes with Diimines and Dipicolinate as Anticancer Cytotoxic Agents.

Natalia Alvarez, Analu Rocha, Victoria Collazo, Javier Ellena, Antonio J Costa-Filho, Alzir A Batista, Gianella Facchin

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Exploring the chemical and biological interplay in phenanthroline-containing copper complexes.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Natalia AlvarezQuímica Inorgánica, Departamento Estrella Campos, Facultad de Química, Universidad de la República, Montevideo 11800, Uruguay.ORCID 0000-0002-6974-2569
Analu RochaDepartamento de Química, Federal University of São Carlos, CP 676, São Carlos 13565-905, SP, Brazil.ORCID 0000-0003-4738-7508
Victoria CollazoQuímica Inorgánica, Departamento Estrella Campos, Facultad de Química, Universidad de la República, Montevideo 11800, Uruguay.
Javier EllenaSão Carlos Institute of Physics, University of São Paulo, Av. do Trabalhador São-Carlense 400, São Carlos 13566-590, SP, Brazil.ORCID 0000-0002-0676-3098
Antonio J Costa-FilhoRIbeirão Preto School of Philosophy, Science and Literature, University of São Paulo, Av. Bandeirantes, Ribeirão Preto 14040-901, SP, Brazil.ORCID 0000-0001-6730-8737
Alzir A BatistaDepartamento de Química, Federal University of São Carlos, CP 676, São Carlos 13565-905, SP, Brazil.
Gianella FacchinQuímica Inorgánica, Departamento Estrella Campos, Facultad de Química, Universidad de la República, Montevideo 11800, Uruguay.ORCID 0000-0002-8960-2694
Universidad de la República de Uruguay · UYUniversidade de São Paulo · BRUniversidade Federal de São Carlos · BR

Funding

Comisión Sectorial de Investigación Científica grant to N.A. and G.FNational Council for Scientific and Technological Development 306682/2018-4 and 312505/2021-3Programa de desarrollo de las ciencias básicas, PEDECIBA, Uruguay finantial suport to N.A and G.FSão Paulo Research Foundation 2015/50366-7 and 2017/15850-0
6 · The paper itself

Abstract

Coordination complexes may act as anticancer agents. Among others, the formation of the complex may facilitate the ligand uptake by the cell. Searching for new copper compounds with cytotoxic activity, the complex Cu-dipicolinate was studied as a neutral scaffold to form ternary complexes with diimines. A series of [Cu(dipicolinate)(diimine)] complexes (where diimine: Phenanthroline, phen, 5-NO

Indexed as

2,2′-dipirydil-amine4,7-diphenyl-1,10-phenanthroline4-methyl-1,10-phenanthrolinebipyridinecopper complexescytotoxic activitydipicolinic acidDNA bindingneocuproinephenanthroline

Identifiers

PMID37242587
PMCPMC10221202
OpenAlexW4367322559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.