ReviewPharmaceutics2023
Piezoelectric Nanomaterials Activated by Ultrasound in Disease Treatment.
Review in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Piezoelectric Nanocoatings on Bio-Interfaces: Microenvironment Remodeling, Biofilm Disruption, and Immunomodulatory Integration.Microorganisms · 2026Review
- Intelligent multimodal-energy-driven piezoelectric antibacterial platforms: From structural control to system-level diagnosis.Materials today. Bio · 2026Review
- Ultrasound-Assisted multimodal neuromodulation via nanosystems.Journal of nanobiotechnology · 2026Review
- MXene Nanomaterial Interfaces: Pioneering Neural Signal Recording for Brain-Computer Interfaces and Cognitive Therapy.Topics in current chemistry (Cham) · 2026Review
- Recent advances in piezoelectric hydrogels for osteoarthritis therapy: material design, signal transduction, and clinical translation.Frontiers in bioengineering and biotechnology · 2026Review
- Ultrasound-driven atherosclerosis nanomedicine: from mechanical, cavitation, and sonodynamic therapies to bedside translation.Journal of nanobiotechnology · 2025Review
- Mechanisms, optimization strategies, and applications of highly sensitive piezoelectric nanomaterials in tumor therapy.Materials today. Bio · 2025Review
- Barium titanate piezoelectric nanoparticles induce M1 polarization in mouse macrophages via ultrasound in vitro.Scientific reports · 2025Article
- Facial nerve pathology: emerging strategies for regeneration and functional restoration.Journal of materials chemistry. B · 2025Review
- BaTiOPharmaceutics · 2025Review
- Ultrasound-activated piezoelectric biomaterials for cartilage regeneration.Ultrasonics sonochemistry · 2025Review
- Piezoelectric Nanomaterials for Cancer Therapy: Current Research and Future Perspectives on Glioblastoma.Journal of functional biomaterials · 2025Review
- An exploration of the ocular mysteries linking nanoparticles to the patho-therapeutic effects against keratitis.Journal of nanobiotechnology · 2025Review
- Wireless Stimulation of Barium Titanate@PEDOT Nanoparticles Toward Bioelectrical Modulation in Cancer.ACS applied materials & interfaces · 2025Article
- Dual-Function Biomaterials for Postoperative Osteosarcoma: Tumor Suppression and Bone Regeneration.Research (Washington, D.C.) · 2025Review
- Recent Advances in Antibacterial Strategies Based on TiOBiomimetics (Basel, Switzerland) · 2024Review
- Engineering 3D Scaffold-Free Nanoparticle-Laden Stem Cell Constructs for Piezoelectric Enhancement of Human Neural Tissue Formation and Function.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Advanced Ultrasound Energy Transfer Technologies using Metamaterial Structures.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Nanomaterials augmented bioeffects of ultrasound in cancer immunotherapy.Materials today. Bio · 2024Review
- Characteristics of Ultrasound-Driven Barium Titanate Nanoparticles and the Mechanism of Action on Solid Tumors.International journal of nanomedicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electric stimulation has been used in changing the morphology, status, membrane permeability, and life cycle of cells to treat certain diseases such as trauma, degenerative disease, tumor, and infection. To minimize the side effects of invasive electric stimulation, recent studies attempt to apply ultrasound to control the piezoelectric effect of nano piezoelectric material. This method not only generates an electric field but also utilizes the benefits of ultrasound such as non-invasive and mechanical effects. In this review, important elements in the system, piezoelectricity nanomaterial and ultrasound, are first analyzed. Then, we summarize recent studies categorized into five kinds, nervous system diseases treatment, musculoskeletal tissues treatment, cancer treatment, anti-bacteria therapy, and others, to prove two main mechanics under activated piezoelectricity: one is biological change on a cellular level, the other is a piezo-chemical reaction. However, there are still technical problems to be solved and regulation processes to be completed before widespread use. The core problems include how to accurately measure piezoelectricity properties, how to concisely control electricity release through complex energy transfer processes, and a deeper understanding of related bioeffects. If these problems are conquered in the future, piezoelectric nanomaterials activated by ultrasound will provide a new pathway and realize application in disease treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.