Evidence map›Paper›PMID 37242423›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Acyl Hydrazides and Acyl Hydrazones as High-Performance Chemical Exchange Saturation Transfer MRI Contrast Agents.

Shaowei Bo, Dong Zhang, Mengjie Ma, Xukai Mo, Julia Stabinska, Michael T McMahon, Changzheng Shi, Liangping Luo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shaowei BoDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, China.ORCID 0000-0002-9193-6220
Dong ZhangMedical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Mengjie MaMedical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Xukai MoMedical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Julia StabinskaThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Michael T McMahonThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-8917-7640
Changzheng ShiMedical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Liangping LuoDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, China.

Funding

Fundamental Research Funds for the Central Universities 21620308Guangdong Basic and Applied Basic Research Foundation 2021A1515111129the National Natural Science Foundation of China 81971672the National Natural Science Foundation of China 82271943th Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation 201905010003
6 · The paper itself

Abstract

Chemical exchange saturation transfer (CEST) MRI is a versatile molecular imaging approach that holds great promise for clinical translation. A number of compounds have been identified as suitable for performing CEST MRI, including paramagnetic CEST (paraCEST) agents and diamagnetic CEST (diaCEST) agents. DiaCEST agents are very attractive because of their excellent biocompatibility and potential for biodegradation, such as glucose, glycogen, glutamate, creatine, nucleic acids, et al. However, the sensitivity of most diaCEST agents is limited because of small chemical shifts (1.0-4.0 ppm) from water. To expand the catalog of diaCEST agents with larger chemical shifts, herein, we have systematically investigated the CEST properties of acyl hydrazides with different substitutions, including aromatic and aliphatic substituents. We have tuned the labile proton chemical shifts from 2.8-5.0 ppm from water while exchange rates varied from ~680 to 2340 s

Indexed as

acyl hydrazidesacyl hydrazonescancer diagnosischemical exchange saturation transfer (CEST)

Identifiers

PMID37242423
PMCPMC10223748

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.