Evidence map›Paper›PMID 37242309›Full record

ArticlePathogens (Basel, Switzerland)2023

The Inherited Intestinal Microbiota from Myeloid-Specific ZIP8KO Mice Impairs Pulmonary Host Defense against Pneumococcal Pneumonia.

Derrick R Samuelson, Deandra R Smith, Kelly C Cunningham, Sabah Haq, Daniel N Villageliú, Christi M Ellis, Niaz Bahar Chowdhury, Amanda E Ramer-Tait, Jeffrey D Price, Daren L Knoell

Open access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Derrick R SamuelsonDepartment of Internal Medicine-Pulmonary Division, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5910, USA.ORCID 0000-0002-5356-1413
Deandra R SmithDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198-6120, USA.
Kelly C CunninghamDepartment of Internal Medicine-Pulmonary Division, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5910, USA.
Sabah HaqDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198-6120, USA.
Daniel N VillageliúDepartment of Internal Medicine-Pulmonary Division, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5910, USA.
Christi M EllisDepartment of Internal Medicine-Pulmonary Division, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5910, USA.
Niaz Bahar ChowdhuryDepartment of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588-0643, USA.
Amanda E Ramer-TaitNebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, NE 68508, USA.ORCID 0000-0003-0950-7548
Jeffrey D PriceNebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, NE 68508, USA.
Daren L KnoellDepartment of Internal Medicine-Pulmonary Division, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5910, USA.ORCID 0000-0002-9977-2857
University of Nebraska–Lincoln · USNebraska Medical Center · USUniversity of Nebraska Medical Center · US

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PAUL L SORGEN · 2012 to 2026
$59.2M
UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Joann B. Sweasy · 1985 to 2026
$55.0M
Gut bacterial metallophores in the development and severity of inflammatory bowel diseaseR01DK131990 · NIDDK · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Derrick R Samuelson · 2022 to 2026
$3.3M
Defective Zn Homeostasis impairs host defense against pneumococcal pneumoniaR01HL156952 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KNOELL, DAREN LEE · 2022 to 2025
$1.5M
Mechanisms by Which Alcohol-Induced Dysbiosis Impairs Host Defense Against Klebsiella PneumoniaeR00AA026336 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SAMUELSON, DERRICK R · 2019 to 2021
$743k
NCI NIH HHS P30 CA036727NHLBI NIH HHS R01 HL156952NIAAA NIH HHS L70 AA031143NIAAA NIH HHS R00 AA026336NIDDK NIH HHS R01 DK131990NIGMS NIH HHS P20 GM103427NIH HHS R00-AA026336NIH HHS R01-DK131990-01NIH HHS R01-HL156952
6 · The paper itself

Abstract

Intestinal dysbiosis increases susceptibility to infection through the alteration of metabolic profiles, which increases morbidity. Zinc (Zn) homeostasis in mammals is tightly regulated by 24 Zn transporters. ZIP8 is unique in that it is required by myeloid cells to maintain proper host defense against bacterial pneumonia. In addition, a frequently occurring ZIP8 defective variant (

Indexed as

gut-lung axishost defensemicrobiomepneumoniazinc transporter

Identifiers

PMID37242309
PMCPMC10222741
OpenAlexW4366987292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.