Evidence map›Paper›PMID 37242259›Full record

ArticleNutrients2023

Antioxidative and Anti-Inflammatory Activities of Rosebud Extracts of Newly Crossbred Roses.

Cuicui Wang, In-Jeong Kim, Hye-Rim Seong, Chan Ho Noh, Sangryong Park, Tae Myoung Kim, Heon Sang Jeong, Ka Young Kim, Seung Tae Kim, Hyun-Gyun Yuk and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
  3. Nonpolysaccharide fraction ofFrontiers in pharmacology · 2026
    Article
  4. Review
  5. Article
  6. Foods (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Cuicui WangCollege of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea.
In-Jeong KimCollege of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea.
Hye-Rim SeongCentral Research Institute, Designed Cells Co., Ltd., Cheongju 28576, Republic of Korea.
Chan Ho NohCollege of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea.
Sangryong ParkCentral Research Institute, Designed Cells Co., Ltd., Cheongju 28576, Republic of Korea.
Tae Myoung KimCentral Research Institute, Designed Cells Co., Ltd., Cheongju 28576, Republic of Korea.
Heon Sang JeongDepartment of Food Science and Biotechnology, Chungbuk National University, Cheongju 28644, Republic of Korea.
Ka Young KimCollege of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea.
Seung Tae KimGumi Floriculture Research Institute, Gyeongsanbuk-do Agricultural Research & Extension Services, Gumi 39102, Republic of Korea.
Hyun-Gyun YukDepartment of Food Science and Biotechnology, Korea National University of Transportation, Jeungpyeong 27909, Republic of Korea.ORCID 0000-0001-9841-7899
Sang-Chul KwonDepartment of Food Science and Biotechnology, Korea National University of Transportation, Jeungpyeong 27909, Republic of Korea.
Ehn-Kyoung ChoiCentral Research Institute, Designed Cells Co., Ltd., Cheongju 28576, Republic of Korea.
Yun-Bae KimCollege of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea.ORCID 0000-0003-1340-041X
Chungbuk National University · KRKorea National University of Transportation · KRGyeongsangnam-do Agricultural Research and Extension Services · KR

Funding

National Research Foundation of Korea 2021RIS-001
6 · The paper itself

Abstract

Oxidative stress and inflammation are basic pathogenic factors involved in tissue injury and pain, as well as acute and chronic diseases. Since long-term uses of synthetic steroids and non-steroidal anti-inflammatory drugs (NSAIDs) cause severe adverse effects, novel effective materials with minimal side effects are required. In this study, polyphenol content and antioxidative activity of rosebud extracts from 24 newly crossbred Korean roses were analyzed. Among them, Pretty Velvet rosebud extract (PVRE) was found to contain high polyphenols and to show in vitro antioxidative and anti-inflammatory activities. In RAW 264.7 cells stimulated with lipopolysaccharide (LPS), PVRE down-regulated mRNA expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and thereby decreased nitric oxide (NO) and prostaglandin E

Indexed as

AntioxidantsPlant ExtractsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalCyclooxygenase 2DexamethasoneHumansInflammationLipopolysaccharidesNitric OxideNitric Oxide Synthase Type IIAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalAntioxidantsCyclooxygenase 2DexamethasoneLipopolysaccharidesNitric OxideNitric Oxide Synthase Type IIPlant Extractsanti-inflammationantioxidationnitric oxidepolyphenolPretty Velvetprostaglandin E2rosebud extract

Identifiers

PMID37242259
PMCPMC10223673
OpenAlexW4377097841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.