Evidence map›Paper›PMID 37242159›Full record

ReviewNutrients2023

Gut Microbial Metabolite Butyrate and Its Therapeutic Role in Inflammatory Bowel Disease: A Literature Review.

Neeraja Recharla, Ramasatyaveni Geesala, Xuan-Zheng Shi

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 154 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed, 6 pooled it
26.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06419231 nacompletednot on this map

A Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of a Butyrate Formulation and a Butyrate + Polyphenol Formulation on Gut Health, Permeability and Associated Symptoms

TypeinterventionalSponsorSupplement Formulators, Inc.Ran2023 to 2025Enrolled143ConditionsGut HealthArmsButyrate Formulation, Butyrate + Polyphenol Formulation, Placebo
NCT07371975 nacompletednot on this mapstarted 2025, after this paper: background citation

A Study to Evaluate the Effects of a Butyrate-Polyphenol Formulation on Gut Health and Associated Symptoms

TypeinterventionalSponsorSupplement Formulators, Inc.Ran2025 to 2026Enrolled124ConditionsGut HealthArmsButyrate + Polyphenol Formulation, Placebo
3 · Its place in the literature

Who cites it

154 citing papers in PubMed, 6 syntheses or guidelines pooled it, 163 citations in OpenAlex.

  1. Pooled it
  2. Short-chain fatty acids in the treatment of ulcerative colitis. Systematic review and meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Pooled it
  3. Pooled it
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  6. Pooled it
  7. Trial
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  9. Oncology research · 2025
    Trial
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  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
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  19. Review
  20. Applied and environmental microbiology · 2026
    Article

94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Neeraja RecharlaDepartment of Internal Medicine, The University of Texas Medical Branch, 301 University Blvd, 4.106 Basic Science Building, Galveston, TX 77555-0655, USA.
Ramasatyaveni GeesalaDepartment of Internal Medicine, The University of Texas Medical Branch, 301 University Blvd, 4.106 Basic Science Building, Galveston, TX 77555-0655, USA.
Xuan-Zheng ShiDepartment of Internal Medicine, The University of Texas Medical Branch, 301 University Blvd, 4.106 Basic Science Building, Galveston, TX 77555-0655, USA.
The University of Texas Medical Branch at Galveston · US

Funding

Pathogenic Role of Mechanical Stress in Fibrosis and Tissue Remodeling in Crohn's DiseaseR01DK124611 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SHI, XUAN-ZHENG PETER · 2020 to 2023
$1.4M
NIDDK NIH HHS DK124611NIDDK NIH HHS R01 DK124611
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Colitis, UlcerativeCrohn DiseaseGastrointestinal MicrobiomeInflammatory Bowel DiseasesAnimalsButyratesInflammationButyratesbutyrategut homeostasisgut microbiotaimmune responsesinflammatory bowel diseasemicrobial metabolitesnutrientsT-cells

Identifiers

PMID37242159
PMCPMC10221771
OpenAlexW4376255499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.