ArticleNutrients2023
Iodine Deficiency, Maternal Hypothyroxinemia and Endocrine Disrupters Affecting Fetal Brain Development: A Scoping Review.
Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- A Modified Iodine Balance Study to Explore the Recommended Nutrient Intake of Iodine in Chinese Preschool Children Aged 3 to 6 Years.Biological trace element research · 2026Trial
- Association of borderline hypertension defined by ACC-AHA diagnostic criteria during pregnancy with neurodevelopment in infants.BMC medicine · 2026Article
- Epidemiological characteristics of congenital hypothyroidism and risk factors for permanent congenital hypothyroidism in Gansu, China.BMC pediatrics · 2026Article
- Micronutrients as Mitigators of Endocrine Disrupting Chemical Health Effects: A Scoping Review and Framework for Epidemiologic Studies.Current environmental health reports · 2026Article
- Iodine Supplementation Before, During and After Pregnancy.Geburtshilfe und Frauenheilkunde · 2026Article
- Adherence to vitamin and dietary supplement intake in fertility and pregnancy care: insights into knowledge, information satisfaction, and formulation variability.Archives of gynecology and obstetrics · 2026Article
- The impact of nutritional, environmental, and lifestyle factors on neurological disorders: therapeutic implications and mechanistic insights.Frontiers in pharmacology · 2026Review
- Beyond iodine nutrition: socioeconomic patterns independently drive thyroid disease risk in pregnant women in Xinjiang.Frontiers in nutrition · 2026Article
- Stage-specific variations in urinary and salt iodine among pregnant women in Beijing.Frontiers in nutrition · 2026Article
- Trimester and sex-specific associations of maternal thyroid profile with neonatal thyroid-stimulating hormone.Endocrine connections · 2025Article
- Gestational hypothyroxinemia causes an inflammatory environment at maternal-fetal tissues and fetal brain with impaired hippocampal dendritic spine maturation in the offspring.Scientific reports · 2025Article
- Serum thyroglobulin levels are predictive of urinary iodine concentration thresholds for defining population iodine status.The British journal of nutrition · 2025Article
- Critical Role of Iodine and Thyroid Hormones During Pregnancy.International journal of molecular sciences · 2025Review
- Key Messages of the Iodine Deficiency Working Group (AKJ): Maternal Hypothyroxinemia Due to Iodine Deficiency and Endocrine Disruptors as Risks for Child Neurocognitive Development.Geburtshilfe und Frauenheilkunde · 2025Article
- Neighborhood deprivation and iodine levels influence air pollution effects on maternal thyroid function in early pregnancy.Environmental research · 2025Article
- Effect of Iodine Nutrition During Pregnancy and Lactation on Child Cognitive Outcomes: A Review.Nutrients · 2025Review
- Multigenerational exposure to trace concentrations of DDT residues in Wistar rats: Effects on biometric development and biochemical parameters.Toxicology reports · 2025Article
- Mild-to-moderate iodine deficiency among pregnant women in Ireland: data from a large prospective pregnancy cohort.European journal of nutrition · 2025Article
- Article
- Expression and Function of Long Non-coding RNA in Endemic Cretinism.Molecular neurobiology · 2025Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This scoping review critically discusses the publications of the last 30 years on the impact of mild to moderate iodine deficiency and the additional impact of endocrine disrupters during pregnancy on embryonal/fetal brain development. An asymptomatic mild to moderate iodine deficiency and/or isolated maternal hypothyroxinemia might affect the development of the embryonal/fetal brain. There is sufficient evidence underlining the importance of an adequate iodine supply for all women of childbearing age in order to prevent negative mental and social consequences for their children. An additional threat to the thyroid hormone system is the ubiquitous exposure to endocrine disrupters, which might exacerbate the effects of iodine deficiency in pregnant women on the neurocognitive development of their offspring. Ensuring adequate iodine intake is therefore essential not only for healthy fetal and neonatal development in general, but it might also extenuate the effects of endocrine disruptors. Individual iodine supplementation of women of childbearing age living in areas with mild to moderate iodine deficiency is mandatory as long as worldwide universal salt iodization does not guarantee an adequate iodine supply. There is an urgent need for detailed strategies to identify and reduce exposure to endocrine disrupters according to the "precautional principle".
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.