Evidence map›Paper›PMID 37241992›Full record

ReviewMolecules (Basel, Switzerland)2023

Recent Progress in the Rational Design of Biothiol-Responsive Fluorescent Probes.

Wenzhi Xie, Jinyu Jiang, Dunji Shu, Yanjun Zhang, Sheng Yang, Kai Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
  3. The Labile Side of Iron in Health and Disease: A Narrative Review.Advances in experimental medicine and biology · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Wenzhi XieHunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, China.
Jinyu JiangDepartment of Chemistry, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China.
Dunji ShuLaboratory of Chemical Biology &Traditional Chinese Medicine Research, Ministry of Education, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China.
Yanjun ZhangDepartment of Chemistry, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China.
Sheng YangHunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, China.ORCID 0000-0003-0867-6438
Kai ZhangDepartment of Chemistry, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China.ORCID 0000-0001-7327-3817
Hunan Normal University · CNSouthwest Medical University · CNChangsha University of Science and Technology · CN

Funding

National Natural Science Foundation of China 21974013Sichuan Science and Technology Program 2018JY0168
6 · The paper itself

Abstract

Biothiols such as cysteine, homocysteine, and glutathione play significant roles in important biological activities, and their abnormal concentrations have been found to be closely associated with certain diseases, making their detection a critical task. To this end, fluorescent probes have become increasingly popular due to their numerous advantages, including easy handling, desirable spatiotemporal resolution, high sensitivity, fast response, and favorable biocompatibility. As a result, intensive research has been conducted to create fluorescent probes for the detection and imaging of biothiols. This brief review summarizes recent advances in the field of biothiol-responsive fluorescent probes, with an emphasis on rational probe design, including the reaction mechanism, discriminating detection, reversible detection, and specific detection. Furthermore, the challenges and prospects of fluorescence probes for biothiols are also outlined.

Indexed as

CysteineFluorescent DyesGlutathioneHomocysteineSpectrometry, FluorescenceCysteineFluorescent DyesGlutathioneHomocysteinebiothiolsdiscriminated detectionfluorescent probereaction mechanismreversible detectionspecific imaging

Identifiers

PMID37241992
PMCPMC10222014
OpenAlexW4378085015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.