Evidence map›Paper›PMID 37241981›Full record

ReviewMolecules (Basel, Switzerland)2023

Application of Rosmarinic Acid with Its Derivatives in the Treatment of Microbial Pathogens.

Ourdia-Nouara Kernou, Zahra Azzouz, Khodir Madani, Patricia Rijo

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Antibacterial Activity of Rosmarinic Acid AgainstAnimals : an open access journal from MDPI · 2026
    Article
  3. Article
  4. Integrated Chemical Profiling and Biological Assessment ofAntibiotics (Basel, Switzerland) · 2026
    Article
  5. Extraction of Phenolic-Rich Fractions fromFoods (Basel, Switzerland) · 2026
    Article
  6. Article
  7. Chemical Composition ofMolecules (Basel, Switzerland) · 2026
    Article
  8. Article
  9. Bioactive Potential ofFood science & nutrition · 2026
    Article
  10. Article
  11. Biological Activities ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Investigating the Health Potential ofPharmaceuticals (Basel, Switzerland) · 2025
    Review
  16. Article
  17. Antineoplastic Activity ofCurrent issues in molecular biology · 2025
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Ourdia-Nouara KernouLaboratoire de Biomathématiques, Biophysique, Biochimie, et Scientométrie (L3BS), Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia 06000, Algeria.ORCID 0000-0003-0767-1491
Zahra AzzouzLaboratoire de Microbiologie Appliquée (LMA), Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia 06000, Algeria.ORCID 0000-0001-5524-238X
Khodir MadaniLaboratoire de Biomathématiques, Biophysique, Biochimie, et Scientométrie (L3BS), Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia 06000, Algeria.ORCID 0000-0001-5356-6890
Patricia RijoCBIOS-Centro de Investigação em Biociências e Tecnologias da Saúde, Universida de Lusófona, Campo Grande 376, 1749-028 Lisbon, Portugal.ORCID 0000-0001-7992-8343
University of Béjaïa · DZUniversity of Lisbon · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence of the antimicrobial resistance phenomena on and the harmful consequences of the use of antibiotics motivate the necessity of innovative antimicrobial therapies, while natural substances are considered a promising alternative. Rosmarin is an original plant compound listed among the hydroxycinnamic acids. This substance has been widely used to fight microbial pathology and chronic infections from microorganisms like bacteria, fungi and viruses. Also, various derivatives of rosmarinic acid, such as the propyl ester of rosmarinic acid, rosmarinic acid methyl ester or the hexyl ester of rosmarinic acid, have been synthesized chemically, which have been isolated as natural antimicrobial agents. Rosmarinic acid and its derivatives were combined with antibiotics to obtain a synergistic effect. This review reports on the antimicrobial effects of rosmarinic acid and its associated derivatives, both in their free form and in combination with other microbial pathogens, and mechanisms of action.

Indexed as

Anti-Infective AgentsAnti-Bacterial AgentsEstersRosmarinic AcidAnti-Bacterial AgentsAnti-Infective AgentsEstersRosmarinic Acidantibiofilmantimicrobial resistancerosmarinic acidsynergistic effect

Identifiers

PMID37241981
PMCPMC10220798
OpenAlexW4378085830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.