ReviewMolecules (Basel, Switzerland)2023
Synthetic Routes to Approved Drugs Containing a Spirocycle.
Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Synthesis of Spiro-Bridged 3,4-Dihydrocoumarins Through an Organocatalytic Cascade Sequence Diels-Alder/Nucleophilic Ring Closing.Molecules (Basel, Switzerland) · 2026Article
- Article
- Selective Functionalization of 1-substituted-3-arylquinoxalin-2(1RSC advances · 2026Review
- Comprehensive Risdiplam Synthesis Overview: From Cross-Coupling Reliance to Complete Palladium Independence.Molecules (Basel, Switzerland) · 2025Review
- Enantioselective Preparation of (Molecules (Basel, Switzerland) · 2025Review
- Enzymatic Stereodivergent Synthesis of Azaspiro[2.y]alkanes.Journal of the American Chemical Society · 2025Article
- A Review of Approaches Developed for Spiroether Synthesis.Topics in current chemistry (Cham) · 2025Review
- Enantioselective Spirocyclization of Pd-Enolates and Isocyanates.Angewandte Chemie (International ed. in English) · 2025Article
- Spirocyclic compounds: potential drug leads in the fight againstFuture medicinal chemistry · 2025Review
- [3 + 2] Cycloaddition of thioformylium methylide with various arylidene-azolones in the synthesis of 7-thia-3-azaspiro[4.4]nonan-4-ones.Beilstein journal of organic chemistry · 2025Article
- Exploring the Reactivity of Rigid 1-Azadienes Derived from Methylene γ-Lactams. Applications to the Stereoselective Synthesis of Spiro-γ-Lactams.The Journal of organic chemistry · 2024Article
- Iodine-Catalyzed Cascade Annulation of 4-Hydroxycoumarins with Aurones: Access to Spirocyclic Benzofuran-Furocoumarins.Molecules (Basel, Switzerland) · 2024Article
- Strain-enabled radical spirocyclization cascades: rapid access to spirocyclobutyl lactones and - lactams.Chemical science · 2024Article
- Entry to new spiroheterocycles via tandem Rh(II)-catalyzed O-H insertion/base-promoted cyclization involving diazoarylidene succinimides.Beilstein journal of organic chemistry · 2024Article
- Evaluation of antibiofilm properties of dehydroacetic acid (DHA) grafted spiro-oxindolopyrrolidines synthesized via multicomponent 1,3-dipolar cycloaddition reaction.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The use of spirocycles in drug discovery and medicinal chemistry has been booming in the last two decades. This has clearly translated into the landscape of approved drugs. Among two dozen clinically used medicines containing a spirocycle, 50% have been approved in the 21st century. The present review focuses on the notable synthetic routes to such drugs invented in industry and academia, and is intended to serve as a useful reference source of synthetic as well as general drug information for researchers engaging in the design of new spirocyclic scaffolds for medicinal use or embarking upon analog syntheses inspired by the existing approved drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.