Evidence map›Paper›PMID 37241928›Full record

ReviewMolecules (Basel, Switzerland)2023

Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery.

Yuehan Yang, Mara Grace C Kessler, Maria Raquel Marchán-Rivadeneira, Yong Han

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Yuehan YangTranslational Biomedical Sciences Program, Ohio University, Athens, OH 45701, USA.
Mara Grace C KesslerEdison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.
Maria Raquel Marchán-RivadeneiraTranslational Biomedical Sciences Program, Ohio University, Athens, OH 45701, USA.ORCID 0000-0002-2495-1703
Yong HanTranslational Biomedical Sciences Program, Ohio University, Athens, OH 45701, USA.ORCID 0000-0003-3833-1473
Biotechnology Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Constantly evolving drug-resistant "superbugs" have caused an urgent demand for novel antimicrobial agents. Natural products and their analogs have been a prolific source of antimicrobial agents, even though a high rediscovery rate and less targeted research has made the field challenging in the pre-genomic era. With recent advancements in technology, natural product research is gaining new life. Genome mining has allowed for more targeted excavation of biosynthetic potential from natural sources that was previously overlooked. Researchers use bioinformatic algorithms to rapidly identify and predict antimicrobial candidates by studying the genome before even entering the lab. In addition, synthetic biology and advanced analytical instruments enable the accelerated identification of novel antibiotics with distinct structures. Here, we reviewed the literature for noteworthy examples of novel antimicrobial agents discovered through various methodologies, highlighting the candidates with potent effectiveness against antimicrobial-resistant pathogens.

Indexed as

Anti-Bacterial AgentsBiological ProductsComputational BiologyDrug Resistance, BacterialGenome, BacterialGenomicsAnti-Bacterial AgentsBiological Productsantibioticsantimicrobial resistancebiosynthesis gene clustersgenome miningnatural products

Identifiers

PMID37241928
PMCPMC10221052
OpenAlexW4377138577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.