Evidence map›Paper›PMID 37241888›Full record

ArticleMolecules (Basel, Switzerland)2023

Targeted Drug Administration onto Cancer Cells Using Hyaluronic Acid-Quercetin-Conjugated Silver Nanoparticles.

Rasha H Al-Serwi, Mohamed A Eladl, Mohamed El-Sherbiny, Mohamed A Saleh, Gamal Othman, Sultan M Alshahrani, Rasha Alnefaie, Afnan M Jan, Sulaiman M Alnasser, Aishah E Albalawi and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 5 countries.

Rasha H Al-SerwiDepartment of Basic Dental Sciences, College of Dentistry, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.ORCID 0000-0002-2121-9269
Mohamed A EladlDepartment of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.ORCID 0000-0002-5675-0842
Mohamed El-SherbinyDepartment of Basic Medical Sciences, College of Medicine, AlMaarefa University, Riyadh 11597, Saudi Arabia.ORCID 0000-0002-0814-1743
Mohamed A SalehDepartment of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.ORCID 0000-0002-6405-6033
Gamal OthmanDepartment of Basic Medical Sciences, College of Medicine, AlMaarefa University, Riyadh 11597, Saudi Arabia.
Sultan M AlshahraniDepartment of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia.ORCID 0000-0002-6194-7092
Rasha AlnefaieDepartment of Biology, Faculty of Science, Al-Baha University, Al Baha 65779, Saudi Arabia.
Afnan M JanDepartment of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Sulaiman M AlnasserDepartment of Pharmacology and Toxicology, Unaizah Colleage of Pharmacy, Qassim University, Buraydah 52571, Saudi Arabia.ORCID 0000-0001-8678-5029
Aishah E AlbalawiDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk 47913, Saudi Arabia.ORCID 0000-0002-7695-8691
Jamal Moideen Muthu MohamedVaasudhara College of Pharmacy, Rajiv Gandhi University of Health Sciences, Sante Circle, Chintamani Road, Hoskote 562114, Karnataka, India.ORCID 0000-0001-6362-8629
Farid MenaaDepartments of Medicine and Nanomedicine, California Innovations Corporation, San Diego, CA 92037, USA.ORCID 0000-0002-0258-7322
Alfaisal University · SAAl Baha University · SACalifornia Medical Innovations Institute · USKing Khalid University · SAMansoura University · EGPrincess Nourah bint Abdulrahman University · SAQassim University · SARajiv Gandhi University of Health Sciences · INUmm al-Qura University · SAUniversity of Sharjah · AEUniversity of Tabuk · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quercetin (QtN) displays low systemic bioavailability caused by poor water solubility and instability. Consequently, it exerts limited anticancer action in vivo. One solution to increase the anticancer efficacy of QtN is the use of appropriate functionalized nanocarriers that preferentially target and deliver the drug to the tumor location. Herein, a direct advanced method was designed to develop water-soluble hyaluronic acid (HA)-QtN-conjugated silver nanoparticles (AgNPs). HA-QtN reduced silver nitrate (AgNO

Indexed as

Biological ProductsMetal NanoparticlesNeoplasmsCaco-2 CellsHumansHyaluronic AcidPolyethylene GlycolsQuercetinSilverSpectroscopy, Fourier Transform InfraredWaterBiological ProductsHyaluronic AcidPolyethylene GlycolsQuercetinSilverWatercytotoxicityfunctional polymer–drug conjugateshemocompatibilitynanodrug delivery systemsoncotargetssilver nanoparticleswater-soluble quercetin

Identifiers

PMID37241888
PMCPMC10221215
OpenAlexW4377104665

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.