ArticleMolecules (Basel, Switzerland)2023
Novel Approach to the Construction of Fused Indolizine Scaffolds: Synthesis of Rosettacin and the Aromathecin Family of Compounds.
Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 7 citations in OpenAlex.
- Total Synthesis and Biological Evaluation of 22-Hydroxyacuminatine and the Related Natural Products Norketoyobyrine and Naucleficine.Molecules (Basel, Switzerland) · 2025Article
- Progress on the Synthesis of the Aromathecin Family of Compounds: An Overview.Molecules (Basel, Switzerland) · 2024Review
- Recent Advances in the Synthesis of Rosettacin.Molecules (Basel, Switzerland) · 2024Review
- Efficient Solvent-Free Synthesis of Indolizines Using CuBr Catalyst from Pyridine, Acetophenone, and Electron-Deficient Alkenes.Molecules (Basel, Switzerland) · 2024Article
- Indole Derivatives: Unveiling New Frontiers in Medicinal and Synthetic Organic Chemistry.Molecules (Basel, Switzerland) · 2023Article
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9 authors at 2 institutions in 1 country.
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Abstract
Camptothecin-like compounds are actively employed as anticancer drugs in clinical treatments. The aromathecin family of compounds, which contains the same indazolidine core structure as the camptothecin family of compounds, is also expected to display promising anticancer activity. Therefore, the development of a suitable and scalable synthetic method of aromathecin synthesis is of great research interest. In this study, we report the development of a new synthetic approach for constructing the pentacyclic scaffold of the aromathecin family by forming the indolizidine moiety after synthesizing the isoquinolone moiety. Thermal cyclization of 2-alkynylbenzaldehyde oxime to the isoquinoline
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